Links to all GeneRIF Items | 3576 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 12513912 (CXCL8) | Elevated serusm levels of this protein in advanced non-small cell lung cancer are related to prognosis. |
| 12576442 (CXCL8) | Upregulation of this cytokine by infiltrating macrophages correlates with tumor angiogenesis and patient survival in non-small cell lung cancer. |
| 15569594 (CXCL8) | IL-8 has a role in tumor microenvironment in lung cancers [review] |
| 15746434 (CXCL8) | both autocrine and paracrine regulation are involved in IL-8 expression of lung cancer cells cocultured with macrophage |
| 16125276 (CXCL8) | We observed a correlation between IL-8 mRNA expression, intratumoral microvessel count and VEGF mRNA expression levels; furthermore, an aberrant p53 status was related to IL-8 expression in patients with non-small cell lung carcinoma. |
| 17207890 (CXCL8) | the differential regulation of expression by PKCalpha/beta in lung adenocarcinoma cells |
| 20044268 (CXCL8) | Serum and bronchoalveolar lavage fluid IL-8 and serum VEGF might have a prognostic role in survival of lung cancer. |
| 20106902 (CXCL8) | IL-8 or IL-8-mediated PLD/PKC/ERK1/2 or PLD/AKT signaling is an attractive therapeutic target for osteolytic bone metastases in lung cancer patients. |
| 20704821 (CXCL8) | Gene expression of IL-8 and MMP-9 is related to the development of non-small cell lung cancer. |
| 21544811 (CXCL8) | Data show that IL-8 overexpression is induced by activating mutations of KRAS or EGFR in non-small cell lung cancer (NSCLC) cells. |
| 21649887 (CXCL8) | The high concentrations of exhaled LTB-4 and IL-8 showed the presence of a neutrophilic inflammation in the airways of NSCLC patients and gave a further support to the inflammatory signalling in lung cancer. |
| 23463594 (CXCL8) | High lipopolysaccharide stimulation of IL8 secretion is associated with metastasis in non-small cell lung cancer. |
| 23688054 (CXCL8) | IL-8 is correlated with lymph node metastasis in malignant pleural effusions of lung cancer patients. |
| 23714383 (CXCL8) | Autocrine IL-8 and VEGF synergistically activate ATF-2 mediated invasiveness in A549 lung cancer cells. |
| 23992011 (CXCL8) | Polymorphism in the 3' -UTR of interleukin 8 is not associated with non small cell lung cancer |
| 24083740 (CXCL8) | High serum IL8 levels are associated with advanced stages of non-small cell lung cancer. |
| 24577055 (CXCL8) | Our findings suggest that IL-8 expression is associated with certain clinicopathological features including age and is a potent prognostic marker in lung adenocarcinoma, especially in oncogenic KRAS-driven adenocarcinoma. |
| 24598169 (CXCL8) | the detection of CD163+ macrophages and pro-angiogenic factors IL-8 and VEGF reflects the local environmental status of host immunity and can be helpful for diagnosis of cancerous inflammation in the lungs |
| 24629040 (CXCL8) | CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC. |
| 25311250 (CXCL8) | Meta-analysis shows that IL-8 -251A/T polymorphism is associated with lung cancer susceptibility in Asians and the -251 A allele may increase risk of lung cancer in Asians. |
| 25817779 (CXCL8) | Studies suggest that the interleukin-8 -251A (CXCL8 protein) allele confer an increased risk for the development of lung cancer among Asians. |
| 27248176 (CXCL8) | IL-8 has a role in lung carcinoma resistance to erlotinib |
| 27811960 (CXCL8) | lung cancer patients showed significantly lower levels of serum VEGF (1.9 fold) and IL-8 (~9 fold) than COPD patients. VEGF level was significantly higher (2.6 fold) in metastatic than non-metastatic cancer patients. An increase in MMP-9 (~1.6 fold) levels was observed in lung cancer patients. |
| 29023999 (CXCL8) | Given that IL-8, MIP-1beta, and MCP-1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.5 exposure may provide insight into the mechanism by which DEE promotes lung cancer. |
| 30305725 (CXCL8) | We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation |
| 31027462 (CXCL8) | These findings support that there is a direct correlation between cytokines including interleukin-6, interleukin-8, interleukin-10, and tumor necrosis factor-alpha and cardiopulmonary bypass time, duration of operation, and intensive care unit stay. |
| 31366916 (CXCL8) | These findings demonstrate that self-seeding osteosarcoma circulating tumor cells (CTCs) can promote tumor growth and lung metastasis through IL-8. Their increased metastatic potential and elevated IL-8 expression suggest a novel strategy for future therapeutic interventions to prevent osteosarcoma progression and metastas |