High survivin expression is associated with lymph node micrometastasis in non-small cell lung cancer.

Stabilization of survivin may contribute to the apoptosis resistance effect of COX-2 in non-small cell lung cancer.

survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells

Survivin-2B specifically expressed in lung cancer tissue and found to specifically elicit a cellular immune response in lung cancer patients

Ehe expression of survivin was potently inhibited by quercetinin non-small cell lung cancer cells.

prognosis of stage I-IIIA non small cell lung cancer may be linked to the cellular pattern of distribution of survivin.

survivin -31C>G polymorphism influences survivin expression, thus contributing to the genetic susceptibility to lung cancer.

Survivin expression is induced as an early event in lung carcinogenesis.

-survivin expression might be a prognostic factor for non-small cell lung cancer

Survivin, Smac, and PKC alpha might play important roles in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells.

survivin expression in non-small cell lung cancer was significantly higher than in normal tissues; survivin mRNA was up-regulated in tumors of 42 patients (66%); survivin overexpression did not correlate with survival of lung cancer

Results suggest that survivin appears to participate in the multidrug resistance mechanism of H460/cDDP lung cancer cells.

BIRC5 is a novel target of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.

survivin may have a role in progression of lung cancer

On the basis of the results obtained the use of exhaled breath condensate COX-2 and survivin levels could be suggested as two potential markers within an early non-invasive screening of populations of smokers at risk of lung cancer.

Upregulation of survivin in non-small cell lung cancer is associated with its neoplasm staging and correlated with p53 and Bcl-2 level.

The positive expression of survivin in nucleus might be associated with invasion, progression and poor prognosis of non-small cell lung cancer.

Ginsenoside Rg3 significantly downregulated the expression of survivin protein in the lung squamous cell carcinoma SK-MES-1 cell line.

Our data suggest that assessment of survivin and second mitochondria-derived activator of caspase mRNA expression may be useful for predicting survival in non-small cell lung cancer patients receiving platinum-based chemotherapy after surgical resection

The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density.

Data suggest that determination of HMGB1, survivin and VEGF concentrations has no clinical significance in the prognosis of the survival time in lung cancer.

SF2/ASF and survivin expression is involved in non-small cell lung cancer progression

Single nucleotide polymorphisms in survivin gene is associated with non-small cell lung cancer.

High survivin expression is associated with adenocarcinomas than in squamous cell subtype of lung cancer.

Data show that ALK inhibitor-induced apoptosis is mediated both by BIM upregulation resulting from inhibition of ERK signaling as well as by survivin downregulation resulting from inhibition of STAT3 signaling in EML4-ALK-positive lung cancer cells.

Cytoplasmic survivin in adenocarcinomas and squamous cell carcinomas could be useful independent prognostic marker in lung neoplasms.

BIRC5 protein expression in tumor samples versus corresponding normal tissue was 1.3 times more often elevated in the squamous cell lung cancer group (in 76% tumor samples).

survivin expression correlated with TNM stage and lymph node metastasis in patients with non-small-cell lung cancer

findings suggest that positive survivin expression may be used as a predictor of a poor response to chemotherapy and shorter survival in lung cancer patients with malignant pleural effusion

Persistent activation of signaling by the AKT-survivin pathway induced by PTEN loss underlies a mechanism of resistance to erlotinib-induced apoptosis in EGFR mutation-positive non-small cell lung cancer.

Survivin expression was not related differentiation, clinical stage, and lymph node metastasis of lung cancer.

survivin and Bcl-2 may act synergistically in the occurrence, development, invasion and metastasis of non-small cell lung carcinoma (NSCLC), both of which are up-regulated in NSCLC tissues

Survivin and livin mRNA levels in patients with lung cancer were significantly higher than in those with benign lung disease.

The Nuclear survivin expression is associated with poor prognosis for Caucasian non-small cell lung cancer(NSCLC) patients.

Survivin overexpression had a poor prognosis value in patients with non-small cell lung cancer. [Meta-analysis]

this study validated the functions of the rs2239680 SNP in the mir-355-related regulation of BIRC5 in Chinese Han with lung cancer.

Our data showed that individuals carrying the survivin 31 GC genotype and those carrying the survivin 644 CC genotype had a significantly decreased risk of having non-small cell lung cancer.

Survivin is overexpressed in blood and tissue of patients with non-small cell lung cancer and is associated with histological type and tumor grade.

Cigarette smoking is associated with the higher nuclear survivin expression in lung adenocarcinomas at the early stage.

survivin and VEGF are over-expressed in small-cell lung cancer and may have a role in tumorigenesis

survivin is expressed in blood and may have a role in response to EGFR-tyrosine kinase inhibitors and prognosis in patients with non-small cell lung cancer

The expression of PIK3CA and survivin had a significant correlation with pathological grade and lymph node metastasis in the primary adenosquamous lung carcinoma patients.

tumor N-survivin expression is a predictive biomarker in the chemotherapy setting as a surrogate marker of high proliferation status in lung cancer.

Co-silencing of Livin and Survivin can effectively inhibit the cell proliferation and apoptosis of lung cancer cells.

Silencing survivin expression inhibits the tumor growth of non-small-cell lung cancer cells in vitro and in vivo.

Selective inhibition of HDAC2 in lung tumor cell causes survivin downregulation through activation of p53, which is mediated by downregulation of Mdm2.

Survivin (-31CC) genotype was associated with significantly increased survivin gene expression and ultimately may contribute in the poor clinical outcome of non-small cell lung cancer patients.

MiR-205/miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and survivin signaling in lung cancer cells.

Survivin -31G/C and 9194A/G polymorphisms were associated with the risk of lung cancer

High surviving expression is associated with adenocarcinoma in non-small cell lung cancer.

Survivin expression was associated with the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) and may serves as an important biomarker for NSCLC progression.

High survivin expression is associated with lung cancer and colorectal cancer.

results showed that survivin genetic variants were related to EGFR mutation in lung adenocarcinoma patients and might contribute to pathological development to NSCLC.

Survivin expression in lung squamous cell carcinoma was increased compared to normal tissue, and was unaffected by methylation status of the surviving gene.

Results identified BIRC5 to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis.

Results form study in non-small-cell lung cancer cells showed that SphK2 plays a critical role in doxorubicin-induced resistance by regulating key anti-apoptotic gene, survivin.

The survivin gene 3' UTR polymorphisms (rs17878624) show that GG genotype provides substantial protection from non-small-cell lung carcinoma.

These findings collectively suggest that the triple combination of survivin knockdown with ABT-263 and trametinib treatment, may be a potential strategy for the treatment of KRAS-mutant lung adenocarcinoma. Furthermore, our findings indicate that the welldifferentiated type of KRAS-mutant lung tumors depends, at least in part, on TTF1 for growth.

results demonstrated that PLAUR induces geftinib-resistance through EGFR/p-AKT/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR could be a novel therapeutic target for gefitinib-resistant NSCLC patients.

High BIRC5 expression is associated with gefitinib resistance in lung cancer.

Overexpressed in tumors, BIRC5 is associated with unfavorable overall survival in triple negative lung adenocarcinomas.

MicroRNA-203 is highly expressed in non-small cell lung cancer (NSCLC) , and is closely related to tumor stage, lymph node metastasis, distant metastasis and poor prognosis of NSCLC patients. It is concluded that microRNA-203 promotes the progression of NSCLC via regulating survivin expression.

Results demonstrate that Survivin is epigenetically modified in non-small cell lung cancer (NSCLC) tissues. A high expression of Survivin on the RNA level was negatively correlated with patients' survival in adenocarcinomas. Also, NSCLC smokers with low expression of Survivin show a better outcome.

Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy.

Combination of radiotherapy and inhibition of survivin and XIAP through the antisense approach results in improved tumor control by radiotherapy in a mouse model of lung cancer.

survivin has a role in preventing sensitization of Lewis lung Carcinoma cells to radiation efficiently

sticky siRNAs against survivin and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 tumors as well as formation and dissemination of melanoma lung metastases.