Results identified HOXA1 loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma.

Study identified HOXA1 as a direct target of miR-30e. Its expression is down-regulated by miR-30e played leading to suppressed lung cancer cell growth.

We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 signaling pathway.

this study illustrates that HOTAIRM1/HOXA1 downregulates the immunosuppressive function of myeloid-derived suppressor celsl and may be a potential therapeutic target in lung cancer.

these results indicated that miR577 may have served tumor suppressive roles in nonsmall cell lung cancer by directly targeting HOXA1.