Links to all GeneRIF Items | 3066 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 22492270 (HDAC2) | findings suggest the aberrant regulation of HDAC2 and its epigenetic regulation of gene transcription in apoptosis and cell cycle components play an important role in the development of lung cancer |
| 23110995 (HDAC2) | X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells |
| 25605253 (HDAC2) | Selective inhibition of HDAC2 in lung tumor cell causes survivin downregulation through activation of p53, which is mediated by downregulation of Mdm2. |
| 27665474 (HDAC2) | Suggest that HDAC2 can trigger migration and invasion of non-small cell lung carcinoma cells by activating NF-kappaB to up-regulate fibronectin expression. |
| 28839465 (HDAC2) | Taken together, these data clearly show that FKBP3/Sp1/HDAC2/p27 control cell proliferation during non-small cell lung cancer development. |
| 31713888 (HDAC2) | The present study found two genetic variants (i.e., HDAC2 rs13213007 G>A and PPARGC1A rs60571065 T>A) in the CREB-binding protein pathway gene-set to be significantly associated with survival of patients with non-small-cell lung cancer. |