Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes

GSTT1-null genotype is a risk factors for lung adenocarcinoma development

specific genotype combinations of CYP1A1, GSTM1 and GSTT1 alleles in the development of lung cancer in heavy smokers

The absense of the GSTT1 gene is not implicated in susceptibility to lung cancer.

Polymorphisms in GSTT1 genotype may increase risk of lung cancer in light smokers and decrease risk for lung cancer overall in heavy smokers.

GSTT1 genotype is associated with increase risk for lung cancer in non-smoking Chinese in Hong Kong.

Role of the metabolic gene polymorphisms in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens.

Our study suggests the importance of combined CYP1A1, GSTM1 and GSTT1 polymorphisms in the development of smoking-induced lung cancer.

genetic polymorphism does not contribute to lung cancer risk in Brazilian population

different combinations of GSTP1, GSTM1 and GSTT1 polymorphisms do not greatly increase risk of lung cancer

GSTT1-null genotype was moderately associated with small cell lung cancer risk.

The GSTT1 -/- genotype along with stage was significantly associated with overall survival and found to be an independent prognostic factor for shorter lung cancer survival.

the presence of null genotype of GSTT1 taken together with CYP1A1 (Val/Val) genotype increases the susceptibility to lung cancer

Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype.

GSTM1 and GSTT1 polymorphisms may play a role in the development of lung cancer for some histological subtypes and modifies the risk of smoking-related lung cancer.

Data show that the distribution of GSTM1 and GSTT1 polymorphisms is not significantly different between lung cancer patients and the controls, suggesting that they are not independent risk factors for lung cancer.

Modifyling effect of GSTT1 polymorphism on the risk of early-onset lung cancer.

Meta-analysis suggests that GSTT1 deletion polymorphisms may have an effect on the susceptibility of lung cancer in Chinese population.

The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstructive pulmonary disease (COPD) and prostate cancer.

The GSTT1 null genotype appeared to play a protective role for lung cancer in several regions of NE India. the GSTT1 null genotype was found to be a significant risk factor for oral & gastric cancer in the Assam region of NE India.

The role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer, was investigated.

Genetic polymorphisms of GSTT1 is associated with lung adenocarcinoma.

decreased activity of GSTM1/GSTT1 enzymes elevates lung cancer risk in male smokers, likely due to impaired carcinogens detoxification

Report possible associations between GSTT1 gene polymorphism and the risk of lung cancer.

Results suggest that genetic polymorphisms in the CYP1A1, GSTM1, GSTT1 and GSTP1 metabolic genes were not significantly associated with lung cancer risk.

These meta-analysis results suggest that GSTT1 null genotype is associated with a significantly increased risk of lung cancer in Asian population.

Studies suggest that the present/null polymorphism in the GSTT1 gene might contribute to the risk of lung cancer in Chinese population.

GSTT1 null genotype is associated with the lung cancer in overall populations and in Asians.

GSTT1 null genotype is associated with the lung cancer in overall populations and in Asians.

GSTT1 appears to influence lung cancer survival whereas GSTM1 seems to have no effect.

GSTT1 null genotypes are risk factors for lung cancer.

GSTT1 deletion polymorphism does not have a significant effect on the susceptibility to lung cancer.

Polymorphisms in GSTT1 and GSTM1 are associated with the risk of lung cancer in a gender-specific manner.

Association of homozygous GSTT1 gene deletion with predisposition to lung cancer was detected in residents of Belarus.

The results suggest that absence of GSTT1 null genotype may be associated with a reduced risk of lung cancer and the effect remains unchanged after interaction with smoking

associations between two vital GSTs genetic polymorphisms and lung cancer risk in the Chinese population

oxidative damage may be play a important role in patients with N-SCLC, and that GSTM1 and glutathione S-transferase M1 and T1 genes genotypes may predispose the cells of patients with non-small lung cancer to increased oxidative damage

Polymorphic variants of GSTP1,GSTM1,GSTP1, and NAT2 genes were accociated with development of occupational lung cancer.

GSTT1 and GSTP1 polymorphisms did not show any significant association with lung cancer

results suggest the polymorphic variants in the CYP1A1 gene along with GSTM1 and GSTT1 do act as a genetic modifier for lung cancer susceptibility and are strongly associated with lung cancer risk in population of North Indians; positive results in the gene-gene interactions analysis seem to indicate that these interactions play an important role with lung cancer development

Data show a combined role of cytochrome P 450 1A1 (CYP1A1), Glutathione -S -transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and smoking status can be attributed for the cause of lung cancer.

The selective effect of PEITC on detoxification in subjects lacking both GSTM1 and GSTT1 genes supports the epidemiologic findings of stronger protection by dietary isothiocyanates against the development of lung cancer in such individuals

No association was found in smoking status and other demographic factors with GSTM1 and GSTT1 deletion because deletion is not specifically found in lung cancer patients but also found in general population as well.

the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma, was investigated.

We assessed the effect of allelic deletions in the GSTM1 and GSTT1 genotypes on lung cancer overall survival through a systematic review of the scientific literature after applying predefined inclusion and exclusion criteria

this meta-analysis indicates that the combined effects of the GSTM1 and GSTT1 polymorphisms are associated with increased lung cancer risk in Asians, Caucasians, and Indians.

Our meta-analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development

Unlike GSTM1, the GSTT1 genotype distribution is associated with the incidence of lung cancer in Iranian people.

Polymorphisms in GSTM1 and GSTT1 influence the response and treatment outcome in lung cancer patients treated with platinum-based chemotherapy.

The genotype combination of GSTT1 (null)/GSTP1 (Ile/Ile) was associated with increased lung cancer risk.

An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer.