To determine the extent of promoter hypermethylation in early lung tumorigenesis, we analyzed promoter methylation status of the p16, death-associated protein kinase (DAPK) and glutathione S-transferase P1 (GSTP1)

Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes

The deficient genotypes for GSTM1 and GSTP1 seem thus to be important risk modifiers for lung cancer, especially in combination.

Associations between carcinogen0-DNA damage, enzyme genotype and risk of lung cancer

In this study, we have used quantitative PCR to analyse expression of beta-tubulin III, stathmin, RRM1, COX-2 and GSTP1 in mRNA isolated from paraffin-embedded tumor biopsies of 75 nonsmall-cell lung cancer patients treated as part of a randomized trial

GST-pi showed no significant relationship with either response rate or survival in patients with unresectable non-small cell lung cancer.

GSTP1 GG increases the lung cancer risk associated with pack-years of smoking

The estimated lung cancer risk for GSTM1 null, GSTP1 Ile/Val and GSTP1 Val/Val combined genotype was 1.44 , implying no effect on lung cancer predisposition.

Decreased expression in reticulocalbin and overexpression in GST-pi with the acquisition of cisplatin-drug resistance in non-small cell lung cancer.

GST-pi expression predicts prognosis in stage I and II squamous cell lung carcinoma, and manipulation of GST-pi may be a potential basis for treatment of some non-small cell lung cancers.

high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients.

Subjects who had the mutant alleles of the GSTP1 and CYP1A1 and homozygous wild type of MPO, showed approximately 5-fold-higher risk for lung cancer than the reference.

Prolonged hypoxia can induce GST-pi expression and increase drug resistance in lung adenocarcinoma cells.

CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.

genetic polymorphism does not contribute to lung cancer risk in Brazilian population

different combinations of GSTP1, GSTM1 and GSTT1 polymorphisms do not greatly increase risk of lung cancer

no significant risk association was found between GSTP1 polymorphism and lung cancer.

Our results do not support significant main and modifying effects for GSTP1 promoter haplotypes on susceptibility to lung cancer in this population.

Modifying effect of GWSTP1 polymorphisms on the risk of early-onset lung cancer.

Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer.

Polymorphisms of GSTP1 and XRCC1 may explain differences in chemosensitivity in Non-small cell lung cancer treated with platinum-based regimens. GSTP1A313G and XRCC1G28152A polymorphisms were significantly associated with response to treatment.

The role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer, was investigated.

Genetic polymorphisms of GSTP1 is associated with lung adenocarcinoma.

Polymorphisms in GSTP1 gene is associated with response to therapy in non small cell lung cancer.

Results suggest that genetic polymorphisms in the CYP1A1, GSTM1, GSTT1 and GSTP1 metabolic genes were not significantly associated with lung cancer risk.

The GSTP1 G allele is associated with the lung cancer susceptibility. [Meta-analysis]

The GSTP1 Ile105Val single nucleotide polymorphism was related to the metabolism of platinum-based chemotherapy, and could be used as predictors of clinical outcome of non-small lung cancer.

this meta-analysis suggests that the GSTP1 341C>T polymorphism may contribute to genetic susceptibility to cancer, especially to lung cancer, and in Asian population

A meta-analysis study concluded that the GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.

GSTP1 Ile105Val polymorphism is associated with lung cancer risk among Asian population and smokers. (Meta-analysis)

Genetic polymorphism of GSTP1 correlated with response to platinum-based chemotherapy in non-small cell lung cancer Chinese patients.

GG genotype was associated with the risk of small-cell carcinoma in Caucasian patients with lung cancer. GSTP1 A/G gene polymorphism is not associated with the susceptibility of small-cell carcinoma in overall populations

Polymorphic variants of GSTP1,GSTM1,GSTP1, and NAT2 genes were accociated with development of occupational lung cancer.

GSTP1 mutations are associated with response to therapy in non-small cell lung cancer patients.

GSTP1 A313G gene polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced non-small cell lung cancer.

the GSTP1 rs1695 and XRCC1 rs25487 polymorphisms might affect the clinical outcome of patients with advanced non-small cell lung cancer receiving cisplatin-based chemotherapy.

This meta-analysis suggests that GSTP1 Ile105Val polymorphism may increase the risk of lung cancer in the Chinese population.

GSTT1 and GSTP1 polymorphisms did not show any significant association with lung cancer

GSTP1 polymorphism was correlated with better response to chemotherapy and lower risk of death in advanced non-small cell lung cancer patients.

the GSTP1 Ile105Val and XRCC1 Arg194Trp were associated with better response to chemotherapy and longer survival of advanced non-small cell lung cancer

we suggest that GSTP1 Ile105Val and XRCC1 Arg399Gln polymorphisms could influence the response to chemotherapy and sur-vival of advanced non-small cell lung carcinoma.

association between polymorphisms in three glutathione S-transferase genes (GSTP1, GSTM1, and GSTT1) and treatment outcome for advanced non-small cell lung cancer. Genotypes of GSTP1 were associated w/ lower risk of disease progression compared with the IIe/IIe genotype. No significant association was observed between GSTM1 and GSTT1 polymorphisms and progression-free survival and overall survival in the NSCLC patients.

The GSTP1 341C/T polymorphism may contribute to lung cancer risk. [meta-analysis]

the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma, was investigated.

The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).

GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.

The present study findings provide the insights that miR133b reduces cisplatin resistance and its overexpression contributes to the suppression of the malignant growth and aggressiveness of cisplatinresistant nonsmall cell lung cancer cells by targeting GSTP1.

GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility.[meta-analysis]

The GSTP1 exon 6 polymorphism correlated with the lung cancer risk.

Correlation of GSTP1 gene variants of male Iraqi waterpipe (Hookah) tobacco smokers and the risk of lung cancer.

The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.