Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes

Glutathione S-transferase mu (GST mu) enzyme detoxifies carcinogens in tobacco smoke. GSTm enzyme positivity rate of the lung cancer patient group (39%) was significantly lower than the control group.

effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk

The deficient genotypes for GSTM1 and GSTP1 seem thus to be important risk modifiers for lung cancer, especially in combination.

association between carcinogen-DNA damage, enzyme genotypes and risk of lung cancer

The GSTM1-null genotype, which confers susceptibility to lung cancer, was associated with shorter survival.

combined GSTM1 null genotype and CYP2E1 Rsa1 wild type has a promoting effect on susceptibility to lung adenocarcinoma

specific genotype combinations of CYP1A1, GSTM1 and GSTT1 alleles in the development of lung cancer in heavy smokers

study the null GSTM1 genotype is an independent risk factor for the development of lung cancer for Turkish population.

The combination of GSTM1 null and GSTP1 Val was significantly associated with an elevated lung adenocarcinoma risk

The estimated lung cancer risk for GSTM1 null, GSTP1 Ile/Val and GSTP1 Val/Val combined genotype was 1.44 , implying no effect on lung cancer predisposition.

The absence of the GSTM1 gene is implicated in susceptibility to lung cancer.

no differences between the patient and control groups regarding genetic polymorphism of genes for non-small cell lung carcinoma

GSTM1 gene is implicated in genetic susceptibility to lung cancer among African American smokers

Polymorphism in GSTM1 had no statistically significant impact on lung cancer risk.

Role of the metabolic gene polymorphisms in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens.

Relative lung cancer risk for the combined 2A/null GSTM1 genotypes was 2.51, which increased with the smoking.

Our study suggests the importance of combined CYP1A1, GSTM1 and GSTT1 polymorphisms in the development of smoking-induced lung cancer.

concerted role of CYP1A1 and GSTM1 at-risk genotypes in squamous cell lung carcinoma predisposition.

Finding suggest of an association between 7-methylguanine excretion and lung cancer risk mainly among current smokers and subjects with GSTM1 null genotype.

we found evidence of an association between the CYP1A1 variant and GSTM1 null genotypes and increased risk of lung cancer.

genetic polymorphism does not contribute to lung cancer risk in Brazilian population

different combinations of GSTP1, GSTM1 and GSTT1 polymorphisms do not greatly increase risk of lung cancer

GSTM1 polymorphisms are associated with lung cancer risk in Asian smokers.

GSTM1 polymorphism did not affect the lung cancer risk.

the presence of null genotype of GSTM1 taken together with CYP1A1 (Val/Val) genotype increases the susceptibility to lung cancer

GSTM1 gene polymorphism is associated with non-small cell lung cancer.

Risk of lung cancer increased as the number of deletion variants increased for GSTM1, although the associations were nonsignificant.

The presence of GSTM1 provides protection against the risk of lung cancer. In addition there is equivocal evidence that this protection varies with the number of gene copies.

GSTM1 and GSTT1 polymorphisms may play a role in the development of lung cancer for some histological subtypes and modifies the risk of smoking-related lung cancer.

findings show that lung cancer risk with higher isothiocyanate intake may be slightly stronger among subjects with deletion of GSTM1

Data show that the distribution of GSTM1 and GSTT1 polymorphisms is not significantly different between lung cancer patients and the controls, suggesting that they are not independent risk factors for lung cancer.

Modifying effect of GSTM1 polymorphisms on the risk of early-onset lung cancer.

Results suggest that GSTM1 and NAT2 genotypes play an independent and interactive role in the formation of carcinogen DNA adduct in the lung.

Findings suggested that CYP1A1 or GSTM1 variants may significantly modify the associations between level of serum trace metals (Cu, Zn, Se or Cr) and NSCLC, indicating the intriguing pathogenesis of lung cancer.

No evidence is found between GSTMI genetic polymorphism and lung cancer risk among Han nationality population in Tianjin district.

Combined effects of cigarette smoke and GSTM1 Polymorphisms are associated with non small cell lung cancer.

The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstructive pulmonary disease (COPD) and prostate cancer.

The GSTM1 null genotype appeared to play a protective role for lung cancer in several regions of Northeast India.

The combination of GSTM1 null genotype and cooking oil fumes significantly increased the risk of female lung cancer.

The combined effects of CYP1A1 gene and GSTM1 gene polymorphism are significantly associated with an increased risk to lung cancer.

Our findings support the hypothesis that a polymorphism in GSTM1 is associated with lung cancer susceptibility.

The role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer, was investigated.

Genetic polymorphisms of GSTM1 is associated with lung adenocarcinoma.

CYP1A1 mutant genotype and GSTM1 null genotype with smoke has increased the risk of lung cancer, with OR being 2.406(1.321-4.382), 2.755(1.470-5.163), respectively.

decreased activity of GSTM1/GSTT1 enzymes elevates lung cancer risk in male smokers, likely due to impaired carcinogens detoxification

The genetic polymorphisms of CYP1A1-exon7, GSTM1, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.

Report possible associations between GSTM1 gene polymorphism and the risk of lung cancer.

the GSTM1 polymorphism plays a role in the development of lung cancer and modifies the risk for smoking-related lung cancer in a Chinese population.

Results suggest that genetic polymorphisms in the CYP1A1, GSTM1, GSTT1 and GSTP1 metabolic genes were not significantly associated with lung cancer risk.

study showed the GSTT1 null polymorphism to be associated with smoking-induced lung cancer and the GSTM1 null polymorphism to have a link with non-smoking related lung cancer

GSTM1 null genotypes are risk factors for lung cancer.

Our study found that the GSTM1 null genotype appeared to be a significant risk factor for lung cancer in East Asia population

Polymorphisms in GSTT1 and GSTM1 are associated with the risk of lung cancer in a gender-specific manner.

The absence of GSTM1 and GSTT1 genes increases the risk of lung cancer because of radon exposure.

Data indicate that both cytochrome P450 1A1 (CYP1A1) MspI and glutathione S-transferase M1 (GSTM1) genetic polymorphisms were independently associated with the risk of lung cancer.

No significant association and gene dosage effect of GSTM1 gene copy number with lung cancer risk ( P trend =0.13) were found.

GSTM1 null genotype was significantly associated with lung cancer risk in a meta-analysis of Asian populations.

associations between two vital GSTs genetic polymorphisms and lung cancer risk in the Chinese population

GSTM1 polymorphisms are associated with lung cancer risk.

oxidative damage may be play a important role in patients with N-SCLC, and that GSTM1 and glutathione S-transferase M1 and T1 genes genotypes may predispose the cells of patients with non-small lung cancer to increased oxidative damage

GSTM1 polymorphisms are not associated with lung cancer risk [meta-analysis]

Polymorphic variants of GSTP1,GSTM1,GSTP1, and NAT2 genes were accociated with development of occupational lung cancer.

GSTM1 deletion polymorphism may contribute to lung cancer risk in the Chinese population. (Meta-analysis)

GSTM1 null genotype was found to be associated with lung cancer

results suggest the polymorphic variants in the CYP1A1 gene along with GSTM1 and GSTT1 do act as a genetic modifier for lung cancer susceptibility and are strongly associated with lung cancer risk in population of North Indians; positive results in the gene-gene interactions analysis seem to indicate that these interactions play an important role with lung cancer development

Data show a combined role of cytochrome P 450 1A1 (CYP1A1), Glutathione -S -transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and smoking status can be attributed for the cause of lung cancer.

The selective effect of PEITC on detoxification in subjects lacking both GSTM1 and GSTT1 genes supports the epidemiologic findings of stronger protection by dietary isothiocyanates against the development of lung cancer in such individuals

No association was found in smoking status and other demographic factors with GSTM1 and GSTT1 deletion because deletion is not specifically found in lung cancer patients but also found in general population as well.

the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma, was investigated.

We assessed the effect of allelic deletions in the GSTM1 and GSTT1 genotypes on lung cancer overall survival through a systematic review of the scientific literature after applying predefined inclusion and exclusion criteria

this meta-analysis indicates that the combined effects of the GSTM1 and GSTT1 polymorphisms are associated with increased lung cancer risk in Asians, Caucasians, and Indians.

Polymorphisms of GSTM1 is associated with lung cancer.

Our meta-analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development

Unlike GSTM1, the GSTT1 genotype distribution is associated with the incidence of lung cancer in Iranian people.

Polymorphisms in GSTM1 and GSTT1 influence the response and treatment outcome in lung cancer patients treated with platinum-based chemotherapy.

Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis.