The inhibition of CK2alpha down-regulates Hh/Gli signaling and subsequently reduces stem-like side population in human lung cancer cells.

While autonomous Gli activity controls non-small cell lung cancer (NSCLC) proliferation, increased Shh expression by NSCLC is associated with fibroblast activation in tumor-associated stroma.

High Gli-1 expression is associated with lymph node metastasis in non-small cell lung cancers.

Gli1 expression is reversely associated with the expression of epithelial-mesenchymal transition markers E-Cadherin and beta-Catenin in lung squamous cell carcinoma specimens.

High expression of GLI1 mRNA was associated with advanced lung adenocarcinoma.

High Gli1 expression is associated with visceral pleural invasion and lymphatic thromboembolism in non-small-cell lung cancer.

Gli may be critical for lung adenocarcinoma metastasis. A novel Gli inhibitor shows promise as a therapeutic agent by preventing cell migration and invasion in vitro and significantly reducing tumor growth and increasing E-Cadherin expression in vivo.

Gli1 expression was significantly correlated with T stage lymph node metastasis, and clinical stage of lung squamous cell carcinoma.

High gli1 expression is associated with Small Cell lung cancer.

High GLI1 expression is associated with Small Cell lung cancer.