expression of pdcd4 as an indirect suppressor of CDK1/cdc2 is lost in progressed carcinomas of lung, breast, colon, and prostate

in squamous cell carcinoma lung cancer lines, alterations in Pdcd4 mRNA and protein levels are not directly linked.

Suppression of tumor suppressor PDCD4 expression may be one of the important regulatory pathways of miR-21-mediated cell proliferation and decrease of apoptosis in non-small cell lung cancer.

role of GSK3beta in Pdcd4 expression lung cancer cells

Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells.

The results of the present study demonstrated that overexpression of miR-182 may be involved in chemoresistance of non-small cell lung cancer cells to cisplatin by down-regulating PDCD4.

PDCD4 inhibits cell growth through PI3K/Akt signaling in non-small cell lung cancer.

Study confirmed that PDCD4 was downregulated in non-small cell lung cancer (NSCLC). PDCD4 is a functional target for miR-155 at both transcriptional and post-transcriptional levels.

Our results suggest that Pdcd4 may perform a critical function in the regulation of lung cancer cell proliferation.

Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis

miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.