Loss of PUMA is associated with lung cancer.

EZH2 directly binds to the Puma promoter thus epigenetically repressing PUMA expression in non-small cell lung cancer cells.

Results show that PUMA expression is downregulated at the translational level by miR-3196 which inhibits lung cancer cells apoptosis.

these results establish a critical role of PUMA in mediating the anticancer effects of deguelin in lung cancer cells and provide the rationale for clinical evaluation.

genetic or pharmacological disruption of alphavbeta3/Src signaling drives PUMA expression, specifically depleting these stem-like tumor cells; increases their sensitivity to apoptosis; and reduces pulmonary metastasis, with no effect on primary tumor growth.

LincRNA-p21 is aberrantly upregulated in non-small cell lung cancer and inhibits cell apoptosis by decreasing PUMA expression.

MiR-222-3p Promotes Cell Proliferation and Inhibits Apoptosis by Targeting PUMA (BBC3) in Non-Small Cell lung cancer.