High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients.

While in the healthy liver hepatocytes are C4.4A negative, data show that C4.4A is strongly expressed in hepatocellular carcinoma (HCC) with upregulation at the invasive front and in lung metastasis, indicating that C4.4A apparently contributes to HCC progression.

Long non-coding RNA OGFRP1 contributed to progression of non-small cell lung cancer at least partly through upregulating LYPD3 expression by sponging miR-124-3p.

The authors explored the related pathways through which LYPD3 affects the pathogenesis and prognosis of lung adenocarcinoma by gene set enrichment analysis, and found that LYPD3 might affect the clinical manifestations of lung adenocarcinoma by regulating the P53 signaling pathway.