Cx43 mRNA in adjacent normal tissue surrounding lung tumor simply detected by RT-PCR may act as a molecular marker of nodal micrometastasis in non-small cell lung cancer.

Results showed that Cx43 was phosphorylated during lung tumorigenesis.

Reduced expression of connexin 43 is associated with lung metastasis in breast cancer

These data suggest that Cx43 inhibits the invasion and metastasis of pulmonary giant cell carcinoma cells by modulating the secretion of FSTL1, which is regulated by histone acetylation.

Cx43 and E-cadherin are reduced with non-small cell lung cancer progression, and might be important biomarkers for judging the metastasis and prognosis.

Cx43 reverses CDDP resistance in A549 CDDP-resistant cells by preventing EMT, making Cx43 a possible therapeutic target for lung cancer.

Novel role for Cx43-formed unidirectional gap junctional intercellular communication was in mediating metabolic coupling between cancer-associated fibroblasts and non-small cell lung cancer cells and thereby facilitating malignant progression of NSCLC by enhancing oxidative phosphorylation and increasing ATP-activated PI3K/Akt and MAPK/ERK signaling pathways.

Decreased expression of CX43 was found in nonsmall cell lung cancer (NSCLC) tissues. Its internalization promoted proliferation, epithelialmesenchymal transition and migration and thus induced NSCLC via aberrant activation of the P53/MDM2 signaling pathway under hypoxic conditions.

tumor suppressor miR613 induces cisplatin sensitivity in nonsmall cell lung cancer cells by targeting GJA1.

knocking out one allele of Cx43 leads to a lower cell to cell communication capacity, and consequently induces a higher cell proliferation which may play a critical role in their susceptibility to lung carcinogenesis

While reduced levels of Cx43 delayed the onset of palpable tumors, normal Cx43 levels inhibited mammary gland tumor metastasis to the lungs.

Loss of connexin 43 expression is associated with lung carcinogenesis.