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Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

2678

PubMed (Gene Name)

Literature evidence

12447480 (GGT1)

Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had significantly increased levels of this enzyme.

27436590 (GGT1)

Formation of LTD4 was rapid when catalyzed by gamma-glutamyl transpeptidase (GGT)1 in the A549 epithelial lung cancer cell line, but considerably slower when catalyzed by GGT5 in primary bronchial epithelial cells. When A549 cells were cultured in the presence of IL-1beta, GGT1 expression increased about 2-fold. Also exosomes from A549 cells contained GGT1 and augmented LTD4 formation.