Links to all GeneRIF Items | 2626 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 15585625 (GATA4) | Hypermethylation of the GATA4 is associated with lung cancer |
| 22018271 (GATA4) | Heterogeneous methylation in the promoter region of GATA4 was associated with cancer progression in non-small cell lung cancer. |
| 23239811 (GATA4) | Results thus identify a novel epigenetic mechanism by which MYC activates GATA4 leading to metastasis in lung adenocarcinoma. |
| 30971692 (GATA4) | Study demonstrates that GATA4 functions as a tumor suppressor in lung cancer. Mechanistically, GATA4 upregulates multiple miRNAs targeting TGFB2 mRNA and causes ensuing WNT7B downregulation and eventually triggers cell senescence. Targeting the TGF-beta signaling provides a potential way for the treatment of GATA4-deficient lung cancer. |