the present findings imply that SIRT1 promotes lung metastasis by facilitating tumor cell migration across a vascular endothelial cell layer.

Results show that SIRT1 facilitates endothelial cell branching and proliferation to increase vessel density and promote lung tumor growth through down-regulation of DLL4/Notch signaling and deacetylation of N1IC.

Study identified a novel pathway that links SIRT1 down-regulation to hypoxia-induced epithelial-to-mesenchymal transition (EMT) in lung cancer cells and may shed light on the development of novel antitumor therapeutics.

this work demonstrates a tumor suppressive role of SIRT1 in the development of K-RAS-driven lung adenocarcinomas in mice and humans.

SIRT1 confers chemoresistance to lung cancer cells by deacetylating and stabilizing XRCC1.

downregulation of Sirt1 decreases survival and increases radiation-induced antiproliferation effects of human lung cancer cells

Our data show the first valid clinical evidence of the deregulation of HIC1-SIRT1-p53 loop in lung tumorigenesis and prognosis

Findings indicate a role of SIRT1 in response to smoke and a potential role in repressing lung cancer.

Suggest that SIRT1 and cortactin may play a role in the progression of non-small cell lung cancer and may cooperate during tumor progression in NSCLC.

Data suggest that the SIRT1 expression may be a molecular marker associated with the non-small cell lung cancer (NSCLC) clinical features, treatment responsiveness and prognosis of advanced NSCLC.

SIRT1 is associated with positive regulation of A549 cells migration and SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancers.

expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients

SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-alpha/beta-catenin axis and is as a potential therapeutic target for lung cancer

Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling, and AKT and p300 negatively regulate this process via Bim upregulation.

celecoxib and sulindac can inhibit TGF-beta1-induced epithelial-mesenchymal transition and suppress lung cancer cell migration and invasion via downregulation of SIRT1

LAT1-NAD+-SIRT1 signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1-FOXO1 apoptotic pathway in response to NQO1

High tumor levels of SIRT1 may be a biomarker for a high pulmonary metastatic rate in osteosarcoma patients.

It may inhibit the proliferation, invasion and migration of lung cancer through downregulation of Sirt1 expression and activation of cell autophagy. The downregulation of miR-138 is closely related to the development of lung cancer

Notably, sirtuin 1 was recognized as a direct downstream target of microRNA-204 in HepG2 cells. Moreover, si-SIRT1 significantly inhibited cell invasion and migration process.his study reveals a novel mechanism by which MALAT1 stimulates hepatocellular carcinoma progression and justifies targeting metastasis-associated lung adenocarcinoma transcript 1 as a potential therapy for hepatocellular carcinoma.

this review underlies the specific mechanisms involved in breast, lung and prostate threatening cancers by microRNAs/SIRT1 pathways. [Review]

Study in human lung cancer lines propose that SIRT1 gene contributes to the tumorigenic potential of lung cancer cells and, in part, determines their sensitivity to the anticancer drug cisplatin in vitro and that sensitivity inversely correlates with SIRT1 expression level- cell lines with lower expression level demonstrated higher sensitivity.

High SIRT1 expression is associated with non-small cell lung cancer.

Cumulatively, these results reveal a novel mechanism of RBM38-mediated regulation of the HIF1A/miR-34a/SIRT1/p53 axis under hypoxia in non-small cell lung cancer cells.