Links to all GeneRIF Items | 23410 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 23842789 (SIRT3) | Loss of SIRT3 expression is associated with lung adenocarcinoma. |
| 24042441 (SIRT3) | High expression of SIRT3 is associated with non-small cell lung cancer. |
| 28197634 (SIRT3) | SIRT3 promotes the malignancy of non-small cell lung cancer, showing an oncogenic preference towards squamous cell carcinoma, and that could represent a novel target for treatment. |
| 31894331 (SIRT3) | Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in smallcell lung cancer. |
| 32229158 (SIRT3) | Study found that SIRT3 can deacetylate mutant p53, thus reducing its expression, inducing apoptosis in small-cell lung cancer (SCLC) cells, and increasing SCLC cisplatin chemosensitivity. The relationship between SIRT3 and mutant p53 could be the basis of a new SCLC treatment approach. |