TSLC1 and DAL-1, two distinct tumor suppressor proteins, directly associate in lung cancer.

DAL-1 methylation is involved in the development and progression of non-small cell lung cancers and provides an indicator for poor prognosis.

methylation of DAL-1 leading to loss of the expression, is an important event in the pathogenesis of non-small-cell lung cancer

The expressions of TSLC1 and 4.1B in non-small cell lung cancer tissues were significantly lower than that in adjacent lung tissues.

Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).

Loss of expression of the differentially expressed in adenocarcinoma of the lung protein is associated with metastasis of non-small cell lung carcinoma.

The results suggest that tumor suppressor DAL-1 could also attenuate epithelial-to mesenchymal transition and be important for tumor metastasis in the early transformation process in lung cancer.

Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3.

Downregulation of DAL-1/4.1B expression effectively suppresses DAL-1/4.1B protein expression in lung cancer cells.

In this study, the expression of 4.1B and its interaction with tumor suppressor in lung cancer-1 were examined in rodent adrenal gland, and the involvement of 4.1B in tumorigenesis