DKK1 may be an important mechanistic link between non-small-cell lung cancer and bone metastases.

Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer.

DKK-1 in serum was a good predictor of poor prognosis in patients with non-small cell lung cancer

DKK1 is differentially expressed amongst various non-small cell lung cancer cells.

We identified dickkopf related protein-1 as a possible marker of a cisplatin-refractory phenotype and as a potential novel therapeutic target to improve platinum response of non small cell lung carcinoma cells.

CKAP4 has a role as a Dickkopf1 receptor and in pancreatic and lung tumor progression

Results found miR-203 and DKK1 to be expressed at differential levels in cisplatin-sensitive and -insensitive lung adenocarcinoma tissues; there was also a negative correlation between them.

Both DKK1 and CKAP4 are frequently expressed in pancreatic and lung tumours, and their simultaneous expression is negatively correlated with prognosis.

these findings suggest that DKK1 induces the occurrence of epithelial-mesenchymal transition and promotes migration and invasion in non-small cell lung cancer cells. Mechanically, b-catenin plays a vital role in DKK1-induced non-small cell lung cancer cell migration and invasion, and DKK1 inhibits the phosphorylation of b-catenin, resulting in the increased nuclear localization of b-catenin.

DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.

rescue assays proved the function of circ_0006427/miR-6783-3p/DKK1 axis in lung adenocarcinoma progression