Links to all GeneRIF Items | 22933 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 23915912 (SIRT2) | Down-regulation of SIRT2 is associated with non-small cell lung cancer. |
| 25915617 (SIRT2) | expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients |
| 28073696 (SIRT2) | The levels of SPOP significantly decreased, while the levels of SIRT2 significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue. |
| 29901178 (SIRT2) | MiR150 plays an important role in the development of lung cancer by serving as an oncogene via the SIRT2/JMJD2A signaling pathway. |
| 31932479 (SIRT2) | The authors propose a mechanism of lung tumorigenesis that involves HRD1-mediated downregulation of SIRT2 and suggest that interventions targeting HRD1 activity could be a potential therapeutic strategy to treat patients with lung cancer. |