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Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

2262

PubMed (Gene Name)

Literature evidence

20304703 (GPC5)

GPC5 polymorphism associated with susceptibility to lung cancer in never smokers

20688270 (GPC5)

No association between GPC5rs2352028 variant and lung cancer in never smokers in meta-analysis of 7 genome-wide association studies under the random effects model.

22236185 (GPC5)

findings suggested that SNP rs2352028 in GPC5 might confer a slight risk to lung cancer/adenocarcinoma

23962560 (GPC5)

Data suggest that glypican-5 (GPC5) is a metastasis suppressor gene in non-small cell lung cancer (NSCLC) and may be a potential biomarker that predicts NSCLC metastasis.

24456789 (GPC5)

Variants in the 50-upstream region of GPC5 confer risk of lung cancer in never smokers

24682381 (GPC5)

GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma.

25999661 (GPC5)

Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.

27157618 (GPC5)

GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt/beta-catenin signaling in lung adenocarcinoma.

27554041 (GPC5)

These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung.

27806326 (GPC5)

Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt/beta-catenin signaling pathway.