Canine tissue factor mRNA was identified and expressed in all canine tumor cells. The highest tissue factor expression and activity were observed in canine mammary tumor cells and pulmonary carcinoma cells.

Case Report: pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor.

Combined oncogene events affecting tumor suppressor genes dramatically increase TF gene expression in lung tumors. Moreover, this study suggests that TF gene expression could be used as a prognostic marker in NSCLC.

Letter: Study suggests that mRNA specific for alternatively spliced TF could be measured in lung tumors together with transcripts specific for full-length TF to evaluate prognosis in patients with non-small cell lung cancer.

Down-regulation of TF using siRNA could provide a potential approach for gene therapy against lung adenocarcinoma.

our results suggest that the pro-angiogenic potential of A549 lung cancer cells is modulated under hypoxic conditions via modulation of TF isoform expression which in turn is controlled by alternative splicing.

TF expression plays a pivotal role in the pathogenesis of MPE generation via regulating of tumor metastasis and vascular permeability in lung adenocarcinoma bearing activated Stat3.