PAR-1 may enhance metastasis of lung cancer through its regulation of cellular proliferation, adhesion and invasion.

PAR-1 may play an important role in the metastasis of lung giant cell carcinoma cells by up-regulating intracellular calcium.

Silencing of PAR1 suppressed invasive stellate growth of lung cancer cells in three-dimensional matrices.

The PAR-1 -14 Ivs A/A genotype was associated with advanced tumor stages and with shorter median survival in squamous cell lung carcinoma.

The serum levels of PAR1 might have a diagnostic value in lung cancer patients

this study demonstrates that TGFbeta is a positive regulator of PAR-1 expression in A549 lung adenocarcinoma cells, which in turn increases the sensitivity of these cells to thrombin signalling

PAR-1 in non-small-cell lung cancer is mainly expressed on cells that constitute the pulmonary tumor microenvironment, including vascular endothelial cells, macrophages and stromal fibroblasts.