Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression.

The combination of p300 and CBP expression may be useful in identifying patients with increased risks of cancer recurrence of small cell lung cancer.

Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling, and AKT and p300 negatively regulate this process via Bim upregulation.

E-cadherin expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail and p300 expressions in lung cancer. Moreover, p300 acetylates Snail both in vivo and in vitro, and K187 may be involved in this modification.

Histone acetyltransferase EP300 is necessary for the transcription factor SOX2 activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.

As a crucial tumor promoter, p300 promotes cell proliferation, migration, and invasion in non-small cell lung cancer cells