progressive increases of tumoral and stromal eIF4E may be part of a positive feedback loop for malignant progression in peripheral lung adenocarcinoma

High eIF4E expression was correlated with poorer overall survival in lung adenocarcinoma patients.

non-small-cell lung cancer patients with eIF4E(+)/cyclin D1(-) have poorer outcome, those with eIF4E(-)/cyclin D1(+) have a more favorable outcome, and those with eIF4E(+)/cyclin D1(+) have an intermediate outcome (P = .02)

There were highly over expression rate of eIF4E, and closely correlated with lymphnode metastasis in NSCLC, which implies that the eIF4E expression may be related to tumorgenesis, invasion and metastasis of lung cancer.

High eIF4F expression is associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.

Pim-1 kinase could be a critical survival signaling factor in non-small-cell lung cancer, and regulated by miR-486-5p and eIF4E.

a link between MYC and mTOR-independent eIF4E contribute to the resistance to everolimus in SCLC cells. Control of the MYC-eIF4E axis may be a novel therapeutic strategy for everolimus action in small cell lung cancer

Our findings identify the eIF4E- beta-catenin axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

Data show that targeting translation initiation (TI) factors eIF4E/eIF4GI reduces migration and epithelial-to-mesenchymal transition (EMT), both essential for metastasis, thereby underscoring the potential of TI targeting in non-small cell lung cancer (NSCLC) therapy.

First study showing the induction of miR-141/EIF4E expression in an acquired model of docetaxel chemoresistant patients with non-small cell lung cancer.

overexpression of (phosphorylated)p-Akt, p-mTOR and p-eIF4E proteins is associated with metastasis and poor prognosis of non-small cell lung cancer patients.

mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.