Links to all GeneRIF Items | 1965 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 22102852 (EIF2S1) | Reduced EIF-2alpha is associated with non-small cell lung cancer. |
| 27542262 (EIF2S1) | eukaryotic elongation factor 2 has a role in proliferation and invasion of lung squamous cell carcinoma |
| 31551255 (EIF2S1) | In response to extracellular amino acid limitation, lung adenocarcinoma cells with diverse genotypes commonly induce ATF4 in an eIF2alpha-dependent manner, which can be blocked pharmacologically using an ISR inhibitor. Although suppressing eIF2alpha or ATF4 can trigger different biological consequences, adaptive cell-cycle progression and cell migration are particularly sensitive to inhibition of the ISR. |
| 31862913 (EIF2S1) | TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2alpha-ATF4 pathway. |