Egr1 is a novel regulator of stathmin expression and p53 mediates the transcriptional repression of stathmin by Egr1 in human lung cancer cells.

Data suggest that EGR-1 plays important roles on VEGF-A expression in lung cancer cells, and epigenetic silencing of transactivator(s) associated with NAB-2 expression might also contribute to upregulate VEGF-A expression.

The absence of ERG rearrangement in bladder or lung small cell carcinomas highlights the utility of detecting ERG rearrangement in small cell carcinomas of unknown primary for establishing prostatic origin.

The PAK5-Egr1-MMP2 signaling pathway is a critical regulator of cell migration and invasion in lung cancer cells.

EGR-1 was observed in the center node of the regulatory network, which seems to play a role in the process of lung cancer metastasis.

KRT18 expression is directly regulated by EGR1, and contributes to decrease malignancy of non-small cell lung carcinoma.

Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling, and AKT and p300 negatively regulate this process via Bim upregulation.

Herbal formula Yangyinjiedu induces lung cancer cell apoptosis via activation of early growth response 1.

The EGR1 mediated EPO-R expression played an essential role in hypoxia-induced non-small-cell lung carcinoma cell proliferation.

Knockout & transgenic mouse models demonstrate roles for Egr1 in fertility, LH production in male mice, stress responses in lung, heart & kidney, and prostate tumors.