Abnormality of the ECT2 gene occurs at a relatively early stage of lung adenocarcinogenesis and would be applicable as a new biomarker for prognostication of patients with lung adenocarcinoma

Ect2 regulates rRNA synthesis through a PKCiota-Ect2-Rac1-NPM signaling axis that is required for lung tumorigenesis.

Investigated and demonstrated that cytoplasmic expression of epithelial cell transforming 2 protein (ECT2) is a characteristic of lung adenocarcinoma with an aggressive malignant phenotype and poor prognosis.

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in lung Squamous Cell Carcinoma.

Protein kinase Ciota promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.

ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling.