thymidylate synthase and dihydropyrimidine dehydrogenase are involved in resistance to 5-fluorouracil in human lung cancer cells

head & neck, gastric, colorectal, breast, lung & pancreatic cancer were examined; findings show mRNA expression & protein level of thymidylate synthase, dihydropyrimidine dehydrogenase & orotate phosphoribosyltransferase differed according to cancer type

Thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase play a role in the prognosis of non-small-cell lung cancer.

tumor expression levels of thymidylate synthetase and dihydropyrimidine dehydrogenase are predictive of response to S-1-carboplatin chemotherapy in patients with advanced non-small cell lung cancer

dihydropyrimidine dehydrogenase has a role in prolonged survival in patients with lung adenocarcinoma treated with 5-fluorouracil

High expression of dihydropyrimidine dehydrogenase in lung adenocarcinoma is associated with mutations in epidermal growth factor receptor and response to chemotherapy.

Results have shown crosstalk among the EGFR cascade and Sp1 and DPD expressions in EGFR mutant non-small-cell lung cancer cell lines. EGF-induced Sp1 up-regulation resulted in both DPYD mRNA and DPD protein expressions.