increased CYP24 expression in lung tumors restricts 1,25D3 activity and support the preclinical evaluation of CYP24 inhibitors for lung cancer treatment

high CYP24A1 mRNA expression in Non Small Cell lung Carcinoma leads to abrogation of antiproliferative effects of 1,25-D3 and ultimately poorer survival

Results provide evidence that CYP24-expressing lung tumors eliminate 1,25(OH)(2)D(3) by a CYP24-dependent process in vivo.

In patients with non-small-cell lung cancer, CYP24A1 SNP rs3787554 (C[T) correlated with disease progression (P = 0.03) and CYP24A1 SNP rs2762939 (C[G) trended toward partial response/stable disease

High CYP24A1 expression is associated with lung adenocarcinoma.

Data show that cytochrome P450 CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in non-small cell lung cancer (NSCLC).

High CYP24A1 expression is associated with lung Adenocarcinoma.

This study shows that polymorphism rs6068616 in CYP24A1 is associated with lung cancer risk in Chinese female nonsmokers. Allele-T is a protective factor, especially in lung adenocarcinoma and advanced lung cancer. Female nonsmoking individuals with CC of rs6068816 who are exposed to oil fume suffer a higher risk of lung cancer, but no gene-environment interaction was found.

The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity.