Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma.

PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer.

PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827.

overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin

Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis.

these results suggest that PEBP4 may promote tumorigenesis in non-small cell lung cancer by regulating cell proliferation and epithelial-to-mesenchymal transition via activation of the Shh signaling pathway.