CYP2A6 genetic polymorphisms is associated with smoking behavior and tobacco-related lung cancer risk

Subjects carrying the CYP2A6*4C allele have lower risk of tobacco-related lung cancer; epidemiological studies indicate that smokers homozygous for the CYP2A6*4C allele show much lower odds ratios toward cancer risk.

CYP2A6 overexpression in human lung cancers correlates with a high malignant status

Variation in CYP2A6 was independently associated with increased cigarette consumption, nicotine dependence, and lung cancer risk. CYP2A6 and CHRNA5-A3-B4 appear to be more strongly associated with smoking behaviors and lung cancer risk, respectively.

data indicate that CYP2A6 deletions may be associated with decreased risk of lung cancer in the Japanese population studied.

there is a clear link between CYP2A6 genotypes, smoking behavior, and lung cancer risk--{REVIEW}

The differential distribution pattern of CYP2A6 in the respiratory tract, which is of importance in considering the pulmonary susceptibility to carcinogens and the following lung cancer development, is detailed.

results indicate that the CYP1A1*2B allele (rs4646903 and rs1048943) is associated with an increased lung cancer risk and CYP2A6*4 is associated with a decreased lung cancer risk in the Bangladeshi population

We did not find statistically significant relationships between CYP2A6 genotypes and lung cancer in studies that included both never smokers and smokers [meta-analysis].

A three-order interaction between CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer risk is found in patients from central south China.

Gene deletion of CYP2A6 might decrease the risk of tobacco-related lung cancer in Asians. [Meta-analysis]

The presence of the CYP2A6 *1/*1 deletion polymorphism might be associated with an increased lung cancer risk, especially for Asians.

lower lung cancer risk observed in CYP2A6 poor metabolizers is partially explained by the strong influence of CYP2A6 genetic polymorphisms on nicotine uptake and metabolism

carcinogen exposure and thereby lower risk of lung cancer. Despite the association between nicotine metabolism (CYP2A6 activity phenotype and diplotypes) and smoking intensity

a greater CYP2A6 activity causes smokers to smoke more extensively and be exposed to higher levels of carcinogens, resulting in an increased risk for lung cancer.

study demonstrated a strong dose-dependent association between reduced CYP2A6 activity determined by genotypes and reduced risk of lung cancer

CYP2A6 activity provides information on lung cancer risk that is not captured by smoking history.

The frequency of slow metabolizers CYP2A6*2 and CYP2A6*9 are poor in the studied Egyptian population. Study findings did not suggest any association between CYP2A6 genotypes and risk of lung cancer in Egyptian population.