The expression of cathepsin B in non-small cell lung cancer should be considered as a significant prognostic parameter.

Central role for the lysosomal protease cathepsin B in mediating cell death in lung cancer cells.

Simultaneous high expression of Cathepsins B and K is associated with recurrence in pulmonary adenocarcinomas and squamous cell carcinomas.

Correlation between higher CTSB expression and lower survival rate in human lung squamous cell carcinoma.

An in vivo role for Ctsb in promoting cellular anaplasia in mammary cancers and proliferation in lung metastases.

Data show that combined loss of Ctsb and Ctsz led to additive effects, resulting in significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading and 70% reduction in the number of lung metastases.