increased expression predicts favorable prognosis in resected nonsmall cell lung carcinoma

in breast and lung tumor cells, MDA-7 protein expression modulates cell-cell adhesion and intracellular signaling via coordinate regulation of the beta-catenin and PI3K pathways

provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression

Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma.

Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors.

Wnt/beta-catenin pathyway is activated by epigenetic inactivation of Dkk3, thereby promoting the growth of lung cancer cells

Core-fucosylated E-cadherin regulated nuclear beta-catenin accumulation in lung cancer cells.

osteopontin nd beta-catenin are useful in differentiating small cell lung carcinomas and non-small cell lung carcinomas

Wnt/beta-catenin signaling plays an important role in lung cancer stem cell properties, and it also regulates OCT-4, a lung cancer stem cell marker.

Knockdown of HDPR1 gene enhanced the invasive ability of lung cancer cells, which was dependent on p120ctn and independent of beta-catenin

Reduced of beta-catenin negative expression relates to dedifferentiation and progression of nonsmall cell lung cancer

Knocking down beta-catenin not only inhibits the Wnt/beta-catenin signal transduction pathway in lung adenocarcinoma A549 cells but also decreases cell proliferation, clone formation and migration capacity.

The expression of DNMT1 was correlated with the cytoplasmic expression of beta-catenin in lung cancer.

High CTNNB1 is associated with non-small cell lung cancer after surgery.

Results suggest that p120ctn isoforms 1 and 3 up-regulate cyclin D1, and thereby cyclin E, resulting in the promotion of cell proliferation and cell cycle progression in lung cancer cells.

The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma.

This is the first demonstration showing YWHAZ through its complex with beta-catenin in mediating lung cancer malignancy and beta-catenin protein stability.

The aim of this study is to evaluate the role of p130cas, E-cadherin, and beta-catenin expression in patients with non-small cell lung cancer.

beta-catenin was cell membrane-bound in normal crypts and colorectal cancer (CRC) neoplastic glands in colon and liver. Many CRC neoplastic glands in lungs expressed beta-catenin in the nucleus, but lacked beta-catenin at the cell membrane.

levels of CD133, CD44, and ALDH1, but not beta-catenin, had independent prognostic value to predict the recurrence of lung adenocarcinoma

our study suggests that evaluation of beta-catenin and MMP-2 expression may have potential in diagnosis and progression in patients with non-small cell lung cancer.

show that IGF-IR-mediated POU5F1 expression to form a complex with beta-catenin and SOX2 is crucial for the self-renewal and oncogenic potentials of lung adenocarcinoma stem-like cells

Loss of CTNNB1 expression is associated with poor response to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in lung cancer.

Upregulation of CTNNB1 is associated with lung cancer invasion.

Data indicate that Kaiso protein participates in the regulation of beta-catenin mRNA expression by interacting with p120-catenin in the lung cancer cell lines.

Deletion of Ctnnb1 significantly inhibits EGFR mutation dependent human lung tumor formation in mice.

The present study implicates beta-catenin promoter hypermethylation in the mechanism of epigenetic changes underlying non-small cell lung cancer metastasis and progression.

Octamer-binding protein 4 affects the cell biology and phenotypic transition of lung cancer cells involving beta-catenin/E-cadherin complex degradation

MicroRNA-33a inhibits lung cancer cell proliferation and invasion by regulating the expression of beta-catenin

Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt/beta-catenin signaling.

Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/beta-catenin signaling pathway.

lung adenocarcinoma tissues derived from gefitinib-resistant patients displayed a tendency to accumulate beta-catenin in the cytoplasm.

SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-alpha/beta-catenin axis and is as a potential therapeutic target for lung cancer

miR-93/ZNRF3/Wnt/beta-catenin regulatory network contributes to the growth of lung carcinoma.

PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression.

Our findings identify the eIF4E- beta-catenin axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

NIFK is required for lung cancer progression via the RUNX1-dependent CK1alpha repression, which activates TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation.

Data show that overexpression of 4.1N protein decreased expression of flotillin-1, decreased activation of beta-catenin/Wnt pathway in non-small-cell lung cancer (NSCLC) cells.

Oct-4 signaling is modulated by nodal via nuclear translocation of beta-catenin in lung and prostate cancer cells

H19 may regulate non-small cell lung cancer (NSCLC) metastasis through modulating cellular signaling pathway proteins related to cell proliferation and cell adhesion, including MACC1, EGFR, beta-catenin and ERK1/2.

PAK1 expression, evaluated by immunohistochemistry, was positively correlated with pERK and beta-catenin expression in lung tumors. Patients with high-PAK1, high-pERK, and high-nuclear beta-catenin tumors more frequently showed an unfavorable response to cisplatin-based chemotherapy when compared to their counterparts.

our findings identify the miR-410/Gsk3beta/beta-catenin signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer

These findings indicate a novel role for zinc regulation in the PKCalpha/beta-catenin pathway and explain an important mechanism for controlling of stem cell program in lung cancer cells.

DDX17 contributes to acquired gefitinib resistance through exportin/importin-dependent cytoplasmic shuttling and activation of beta-catenin in non-small lung cancer cells.

Indicate that beta-catenin and SATB2 are useful immunohistochemical markers for differentiating between pulmonary enteric adenocarcinoma and metastatic colorectal carcinoma.

MiR-128-3p overactivates the beta-catenin pathway in the non-small cell lung cancer cells.

these findings suggest that DKK1 induces the occurrence of epithelial-mesenchymal transition and promotes migration and invasion in non-small cell lung cancer cells. Mechanically, b-catenin plays a vital role in DKK1-induced non-small cell lung cancer cell migration and invasion, and DKK1 inhibits the phosphorylation of b-catenin, resulting in the increased nuclear localization of b-catenin.

MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/beta-catenin pathway in non-small cell lung cancer

using a xenograft mouse model, baicalin markedly reduced liver and lung metastasis of breast cancer, inhibited expression of beta-catenin, and degraded the EMT molecules vimentin and Slug in the orthotopic tumor tissues. Taken together, all these results indicate that baicalin effectively suppresses the metastasis of breast cancer by reversing EMT, which may be mediated by downregulation of beta-catentin expression.

Associations between environmental variants together with single nucleotide polymorphisms (SNPs) of beta-catenin (ctnnb1) and lung cancer risk were analyzed using a logistic regression model.

High CTNNB1 expression is associated with cisplatin-resistance in non-small cell lung cancer.

CTNB role in the non-small-cell lung cancer cells drug resistance to TRAIL.

This study demonstrates that FOXC1 induces cancer stem cells (CSCs)-like properties in non-small cell lung cancer (NSCLC) by promoting beta-catenin expression. The findings indicate that FOXC1 is a potential molecular target for anti-CSC-based therapies in NSCLC

Results show that hypoxia enhanced nuclear accumulation and transcriptional activity of beta-catenin which promotes expression of EMT-related genes and eventually contributes to the metastatic process in lung cancer cells.

the present study demonstrates that up-regulation of GPC3 accelerates the progression of lung squamous cell carcinoma (SCC) in a b-catenin-dependent manner. Our study provides a theoretical basis for GPC3/b-catenin as a novel diagnostic marker and therapeutic target for lung SCC

Actinomycin D and Telmisartan Combination Targets lung cancer Stem Cells Through the Wnt/Beta Catenin pathway.

WDR74 induces nuclear beta-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis.

STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/betacatenin pathway and feedback regulation by cmyc.

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/beta-catenin signaling.

lncRNA SNHG11 promotes lung cancer cell proliferation and migration via activation of Wnt/beta-catenin signaling pathway.

Cyclin K interacts with beta-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer.

activation of Wnt/beta-catenin signaling can combine with other oncogenic pathways in lung epithelium to produce a more aggressive tumor phenotype by imposing an embryonic distal progenitor phenotype and by decreasing E-cadherin expression

Fgfr3 mutation caused papilloma and promoted lung tumorigenesis in cooperation with K-Ras and beta-catenin activation, respectively.

lysyl oxidase proenzyme is shown to negatively regulate pro-oncogenic beta-catenin signaling in lung cancer cells.

Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating beta-catenin mediated by upregulated HOTAIR.

Ginkgo biloba exocarp extract inhibits tumor angiogenesis, which may be closely relevant to its effect in blockage of Wnt /beta-catenin-VEGF signaling pathway in Lewis lung carcinoma.

Zi Shen Decoction Inhibits Growth and Metastasis of lung cancer via Regulating the AKT/GSK-3beta/beta-Catenin pathway.