Our studies demonstrate that a collagen-I-dense ECM can potently alter hormonal signals to drive the progression of ERalpha + breast cancer, increasing intravasation and pulmonary metastases.

High serum and urine levels of cross-linked N-telopeptide of type I collagen is associated with bone metastasis in lung cancer.

our data revealed that COL1A1, UCP2, and PRPF40A are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer

DNMT1 was downregulated in the lung cancer group and its expression was further reduced in the presence of increasing malignant burden as indicated by the endobronchial findings further suggesting an lung cancer-specific signature.

High COL1A1 mRNA expression is associated with lung and esophageal cancers.