CHRNA5 and CHRNA3 are promising candidate genes in the region of 15q25.1 for lung cancer.

smokers who carry the CHRNA3 and CHRNA5 variants are expected to be at increased risk for lung cancer compared with smokers who do not carry these alleles.

Single Nucleotide Polymorphism in CHRNA3 is associated with non-small cell lung cancer.

single nucleotide polymorphisms influence treatment outcome in advanced non-small-cell lung cancer patients

Single nucleotide polymorphisms in the CHRNA3 gene is associated with lung cancer.

This review focuses on the clustered nicotinic acetylcholine receptor genes CHRNalpha5/alpha3/beta4 and evaluates their role in nicotine addiction and lung cancer.

CHRNA3-CHRNA5 variation impacts indirectly on lung cancer risk

Polymorphisms in CHRNA3 gene is associated with lung squamous cell carcinoma.

Nicotinic acetylcholine receptor polymorphisms are associated with additional increased risk of lung cancer, bladder cancer, and chronic obstructive pulmonary disease after adjustment for smoking.

Variation in CHRNA5-A3-B4 was independently and additively associated with increased smoking, nicotine dependence, and lung cancer risk.

Thia case-control analysis revealed that an increased risk of lung cancer is associated with an SNP in CHRNA3, rs8040868.

CHRNA3 gene rs1051730-A allele might be a risk-conferring factor for the development of lung cancer in Caucasians, but not in East-Asians.

CHRNA3 polymorphism on chromosome 15q25 is associated with early stage non-small-cell lung cancer.

CHRNA3 gene rs3743073G variant genotype significantly increased lung cancer risk, especially in male smokers over the age of 60.

Data show a statistical association and suggest biological plausibility that the CHRNA3 rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer.

The subjects carrying the minor "A" allele on rs1051730 in CHRNA3 may be at risk to develop COPD and/or lung cancer as well as nicotine-dependence.

rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population.

Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese.

the haplotype analysis found that the haplotypes "TCAC" and "CTGT," composed of rs938682, rs12914385, rs11637630, and rs2869546, were associated with a 1.79-fold and 501-fold increased lung cancer risk

both rs578776 and rs938682 of CHRNA3 were significantly associated with the susceptibility of lung cancer.

two SNPs (rs6495308 and rs11072768) in CHRNA5-A3-B4 have a indirect effect on lung cancer through smoking behaviors

CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.

Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls.

CHRNA3/5 polymorphisms are associated with nicotine dependence, lung cancer, and chronic obstructive pulmonary disease in Mexicans.

Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With lung cancer.

The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review.