The expression of PHD genes and their relationship with the tumor behavior and apoptosis-associated factors in non-small cell lung cancer, was investigated.

Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.

PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation.

Study consistently found that hypermethylation at cg25923056-EGLN2 downregulated the corresponding gene EGLN2 expression in lung adenocarcinomas (LUAD) tumor tissues. Meanwhile, EGLN2 expression was negatively correlated with HIF1A expression in tumor tissues and significantly interacted with HIF1A expression on overall survival.