Data indicate that concordant transforming growth factor-beta1 (TGFbeta-1) positive and EH-domain containing 1 (EHD1) negative as a strong favorable prognosis factor in non-small cell lung cancer (NSCLC).

this study shows that overexpression of EHD1 induced the epithelial-mesenchymal transition and increased the metastatic potential of lung cancer cells in vitro and in vivo

EHD1 may be an independent prognostic marker in lung cancer and that the NF-kappaB/miR-590/EHD1 signalling pathway might be a potentially effective therapy for overcoming EGFR-TKI resistance.

the data obtained in this study suggest that EHD1 plays a critical role in Non-small cell lung cancer (NSCLC) angiogenesis via b2AR signaling and highlight a potential target for antiangiogenic therapy.