Findings establish a functional contributio of G9a overexpression with concomitant dysregulation of epigenetic pathways in lung cancer progression.

Low G9a expression is associated with lung and colonic cancer.

study uncovers a novel mechanism of G9A promoting tumor cell growth and invasion by silencing CASP1, and implies that G9A may serve as a therapeutic target in treating Non-small-cell lung cancer.

The study identified that decreased expression of SATB2 was correlated with tumor progression and poor prognosis in non-small cell lung cancer (NSCLC) patients. Furthermore, SATB2 suppressed lung cancer cell invasion and metastasis and regulated the expression of EMT-related proteins and histone methylation by G9a.

EHMT2 expression and enzymatic activity levels were elevated in EGFR-tyrosine kinase inhibitor-resistant non-small cell lung cancer cells.

Overexpression of Snail2 enhanced the migration and invasion ability in lung carcinoma, whereas G9a and Histone Deacetylase inhibition significantly reversed this effect.