nestin expressed in most tumor cells of non-small cell lung cancer tissue and had a direct linkage to lymph node metastasis and tumor-induced lymphangiogenesis, independent of COX-2 signal pathway.

Nestin is significantly higher in lung adenocarcinoma patients especially with advanced grade and stage.

nestin correlates with the aggressiveness and stemness of lung adenocarcinoma.

Data indicate that nestin expression in non-small cell lung cancer (NSCLC) cells is associated with poor prognosis of patients and tumor cell proliferation pathway.

The authors found that high/positive SOX2 alterations, either DNA amplification or protein expression, were favorable for overall survival (OS) in non-small cell lung cancer. On the contrary, high/positive Nestin protein expression was poor for OS.