POSTN promotes the pulmonary accumulation of myeloid-derived suppressor cells (MDSCs) during the early stage of breast tumour metastasis. Postn deletion decreases neutrophil and monocytic cell populations in the bone marrow of mice and suppresses the accumulation of MDSCs to premetastatic sites.

Results indicate that periostin is a key player in the development of bleomycin-induced fibrosis and consequent enhancement of tumor cell colonization in the lung.

periostin promoted the survival of A549 non-small-cell lung cancer cells under hypoxic microenvironment via activation of Akt/PKB pathway

Periostin is a novel molecular which play an important role during the progression and development of non-small cell lung cancer .

Data show that periostin was significantly upregulated in cisplatin-resistant A549 cells and provide evidence for the involvement of periostin in cysplatin resistance in non-small cell lung cancer cells.

our study suggests that serum periostin could be considered as a diagnostic and prognostic marker for non-small cell lung cancer patients.

Baseline periostin and periostin responses appeared to be reliable surrogate markers to predict chemotherapy response and survival in patients with advanced non-small cell lung cancer.

The study demonstrated that down-regulation of Periostin expression modulated tumor microenvironment and inhibited bone metastasis by blocking integrin-signaling pathway in lung cancer

the diagnostic sensitivity and specificity of pleural fluid periostin (pPOSTN) and serum periostin (sPOSTN) in malignant pleural effusion (MPE) caused by non-small-cell lung cancer (NSCLC), was examined.

Prognostic Significance of Stromal Periostin expression in Non-Small Cell lung cancer.