lung cancer gene and literature database Home
Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

10516

PubMed (Gene Name)

Literature evidence

25909283 (FBLN5)

Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt/beta-catenin signaling.

30305430 (FBLN5)

Fibulin-5 silencing in non-small-cell lung cancer cells is due to the hypermethylation of its promoter through 2-hydroxyglutarate, production of which arises from a mutation in IDH1.