A transgenic mouse line expressing a dominant negative A-C/EBP was subjected to NNK induced lung carcinogenesis bioassay, and the effect of abolition of DNA binding activities of C/EBPs on lung carcinogenesis was examined.

Down-regulation and antiproliferative role of C/EBPalpha in lung cancer.

DNA hypermethylation of the upstream C/EBPalpha promoter region, not the core promoter region as previously reported, is critical in the regulation of C/EBPalpha expression in human lung cancer.

TRIB2 as a potential driver of lung tumorigenesis through a mechanism that involves downregulation of C/EBPalpha

CCAAT/enhancer-binding protein-alpha suppresses lung tumor development in mice through the p38alpha MAP kinase pathway.

CUGBP1 promotes cell proliferation and suppresses apoptosis via down-regulating C-EBPalpha in human non-small cell lung cancers.