Data suggest that PRMT5 is highly expressed in lung cancer cells; PRMT5 expression is not detectable in benign lung tissues. Silencing PRMT5 expression strongly inhibits proliferation of lung adenocarcinoma cells in culture and in a xenograft model.

PRMT5 is significantly overexpressed in neoplastic lung tissues supporting its role in lung tumorigenesis.

Results provide evidence that PRMT5 and p44 regulate gene expression of growth and anti-growth factors to promote lung tumorigenesis.

Studies suggest that the protein arginine N-methyltransferase 5 (PRMT5)/miR-99 family/fibroblast growth factor receptor 3 (FGFR3) axis in regulating lung cancer progression and identifies PRMT5 as a promising prognostic biomarker and therapeutic target.

High PRMT5 expression is associated with lung cancer.

PRMT5 Promotes Human lung cancer Cell Apoptosis via Akt/Gsk3beta Signaling Induced by Resveratrol.