Data suggest that microRNA 137 influences cell proliferation via regulation of expression of CDK6 and CDC42 (cell division cycle protein 42); expression of microRNA 137 in lung cancer cells downregulates CDK6/CDC42 and induces G1 cell cycle arrest.

lower expression in cisplatin-resistant non-small-cell lung carcinoma

only miR-34a was prognostic for RFS (RR, 11.5; P = 0.027). miR-34a expression was inversely correlated with that of c-MET and CDK6 in non-small cell lung cancer , and had prognostic significance for RFS, especially in adenocarcinoma patients.

these data provide evidence that TRIM59 is involved in lung carcinoma growth and progression possibly through the induction of CDK6 expression and epithelial-to-mesenchymal transition (EMT) process by activation of ERK pathway.

lncRNA HNF1A-AS1 modulates non-small cell lung cancer progression by targeting miR-149-5p/Cdk6.

LncRNA AWPPH accelerates the progression of non-small cell lung cancer by sponging miRNA-204 to upregulate CDK6.