Nuclear DRP1 is highly expressed in lung adenocarcinomas, and correlates with poor prognosis.

Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer mode.

Results suggest that the loss of dynamin-related protein 1 (Drp1) expression could contribute to the development of lung and colon cancers.

Drp1 was highly expressed in lung cancer based on bioinformatics analysis and tissue microarray. However, prognosis showed inconsistent results in which high expression of Drp1 was correlated with worse survival probability of all, male, female in lung Adenocarcinoma, but not in lung Squamous Cell Carcinoma.

DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.

Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.