high level of CD24 expression is associated with nonsmall cell lung cancer

High CD24 is associated with non-small cell lung carcinoma.

Our results suggest that the decreased expression of NDRG2 or the increased expression of CD24 is an important feature of lung adenocarcinoma.

CD24 positivity can accurately discriminate malignant mesothelioma from pulmonary adenocarcinoma.

CD24(high) tumor cells formed tumors in mice at a faster rate than CD24(low) tumor cells, and shRNA-mediated knockdown of CD24 in HT29 cells confirmed a functional requirement for CD24 in the colonization of the lung.

Study have shown that CD24 is highly expressed in a bone metastatic lung cancer cell line, promotes anchorage-independent growth and adhesion in vitro, and that CD24-knockdown suppressed bone metastasis of lung cancer cells in vivo.

Results determined that CD24 expression was elevated in highly lung and lymph node metastatic triple-negative breast cancer (TNBC) cells, and unveiled the important role of CD24 in TNBC progression and metastasis via a novel mechanism of CD24/Met/EGFR-mediated lymphangiogenesis and angiogenesis in the tumor microenvironment.

CD24, not CD47, negatively impacts upon response to PD-1/L1 inhibitors in non-small-cell lung cancer with PD-L1 tumor proportion score < 50.