data suggests that miR-365 suppresses the expression and therefore the oncogenic functions of NKX2-1 in lung cancer

Aberrant expression of mir-365/TTF-1 may be involved in the tumor development in patients with non-small cell lung carcinoma.

NKX2-1 expression was upregulated in never-smokers , lung adenocarcinoma and patients with wild-type TP53. A negative correlation between NKX2-1 and miR-365 expression was found but there was no correlation between NKX2-1 and miR-33a expression. NKX2-1 expression impacts prognosis in early-stage non-small cell lung cancer patients, particularly in those with neither TP53 nor KRAS mutations.

Overexpression of miR-365 is able to enhance the radiosensitivity of non-small cell lung cancer (NSCLC) cells through targeting CDC25A. We found that the expression level of miR-365 was positively correlated with the radiosensitivity of NSCLC cell lines.

miR-365 suppressed the expression of TRIM25 and elevated the expression of the proapoptotic protein in non-small-cell lung cancer cells.

MicroRNA-365 inhibits the progression of lung adenocarcinoma through targeting ETS1 and inactivating AKT/mTOR pathway.