lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9961
Symbol	MVP
Synonymous	LRP\|VAULT1
Full name	major vault protein
Gene description	lung resistance-related protein
Cytoband	16p11.2
Gene type	protein-coding
Synonymous	MIM:605088; HGNC:HGNC:7531; Ensembl:ENSG00000013364; HPRD:05475; Vega:OTTHUMG00000048227

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.359C>G; p.A120G; 16:29833770-29833770	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.22A>G; p.I8V; 16:29830571-29830571	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2016G>T; p.A672A; 16:29844874-29844874	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.689G>A; p.R230Q; 16:29836738-29836738	lung	carcinoma; mucoepidermoid_carcinoma	Substitution - Missense
c.1508G>A; p.G503E; 16:29841986-29841986	liver	carcinoma	Substitution - Missense
c.2026G>A; p.E676K; 16:29845867-29845867	skin	malignant_melanoma	Substitution - Missense
c.1508G>A; p.G503E; 16:29841986-29841986	liver	carcinoma	Substitution - Missense
c.2350G>A; p.A784T; 16:29847281-29847281	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1341G>T; p.Q447H; 16:29841745-29841745	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.816C>A; p.P272P; 16:29836865-29836865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2297G>A; p.R766Q; 16:29847228-29847228	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1843G>A; p.D615N; 16:29844701-29844701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1708G>A; p.D570N; 16:29844566-29844566	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1436G>T; p.R479L; 16:29841840-29841840	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2055C>T; p.R685R; 16:29845896-29845896	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.766A>G; p.T256A; 16:29836815-29836815	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2417C>G; p.T806S; 16:29847348-29847348	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.374C>T; p.A125V; 16:29833785-29833785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.78C>T; p.S26S; 16:29830627-29830627	skin	malignant_melanoma	Substitution - coding silent
c.1366C>T; p.R456C; 16:29841770-29841770	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1597G>A; p.D533N; 16:29842075-29842075	skin	malignant_melanoma	Substitution - Missense
c.2406A>G; p.I802M; 16:29847337-29847337	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.78C>T; p.S26S; 16:29830627-29830627	skin	malignant_melanoma	Substitution - coding silent
c.2600G>A; p.S867N; 16:29847907-29847907	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.900C>T; p.R300R; 16:29836949-29836949	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1354C>T; p.R452W; 16:29841758-29841758	skin	malignant_melanoma	Substitution - Missense
c.1887C>T; p.P629P; 16:29844745-29844745	skin	malignant_melanoma	Substitution - coding silent
c.1725C>T; p.I575I; 16:29844583-29844583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2678G>A; p.R893H; 16:29847985-29847985	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.2178C>T; p.A726A; 16:29846197-29846197	thyroid	other; neoplasm	Substitution - coding silent
c.375G>A; p.A125A; 16:29833786-29833786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2178C>T; p.A726A; 16:29846197-29846197	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.898C>G; p.R300G; 16:29836947-29836947	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2566C>T; p.Q856*; 16:29847873-29847873	skin	malignant_melanoma	Substitution - Nonsense
c.1464G>A; p.S488S; 16:29841942-29841942	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1464G>A; p.S488S; 16:29841942-29841942	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.894G>T; p.Q298H; 16:29836943-29836943	thyroid	other; neoplasm	Substitution - Missense
c.608C>T; p.A203V; 16:29835734-29835734	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>T; p.R175W; 16:29834012-29834012	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2358G>A; p.Q786Q; 16:29847289-29847289	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1436+8C>G; p.?; 16:29841848-29841848	pancreas	carcinoma	Unknown
c.1497C>T; p.S499S; 16:29841975-29841975	skin	malignant_melanoma	Substitution - coding silent
c.1956C>T; p.D652D; 16:29844814-29844814	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.244C>T; p.R82W; 16:29830996-29830996	skin; nipple	malignant_melanoma	Substitution - Missense
c.2677C>T; p.R893C; 16:29847984-29847984	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.146G>A; p.R49H; 16:29830898-29830898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1086C>A; p.P362P; 16:29840354-29840354	breast	carcinoma	Substitution - coding silent
c.2389C>T; p.Q797*; 16:29847320-29847320	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1747G>A; p.V583M; 16:29844605-29844605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606G>T; p.G202G; 16:29835732-29835732	thyroid	other; neoplasm	Substitution - coding silent
c.749T>G; p.L250R; 16:29836798-29836798	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1149C>T; p.D383D; 16:29840417-29840417	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.994C>A; p.L332M; 16:29840262-29840262	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.435C>T; p.F145F; 16:29833846-29833846	breast	carcinoma	Substitution - coding silent
c.815C>T; p.P272L; 16:29836864-29836864	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1495T>C; p.S499P; 16:29841973-29841973	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1798C>T; p.R600C; 16:29844656-29844656	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1798C>T; p.R600C; 16:29844656-29844656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1192-1G>A; p.?; 16:29841595-29841595	urinary_tract; bladder	carcinoma	Unknown
c.1778A>G; p.K593R; 16:29844636-29844636	skin	malignant_melanoma	Substitution - Missense
c.250C>T; p.R84C; 16:29831002-29831002	oesophagus	carcinoma	Substitution - Missense
c.1450C>T; p.P484S; 16:29841928-29841928	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.351C>A; p.P117P; 16:29833762-29833762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1842C>T; p.P614P; 16:29844700-29844700	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.34C>T; p.P12S; 16:29830583-29830583	thyroid	other; neoplasm	Substitution - Missense
c.1735G>T; p.V579L; 16:29844593-29844593	urinary_tract; bladder	carcinoma	Substitution - Missense
c.292C>T; p.P98S; 16:29831044-29831044	skin	malignant_melanoma	Substitution - Missense
c.730C>T; p.R244C; 16:29836779-29836779	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.2039_2040delTG; p.L680fs*9; 16:29845880-29845881	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2039_2040delTG; p.L680fs*9; 16:29845880-29845881	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.536G>A; p.R179H; 16:29834025-29834025	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2112G>T; p.K704N; 16:29845953-29845953	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.897G>A; p.K299K; 16:29836946-29836946	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1387C>A; p.P463T; 16:29841791-29841791	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2534C>T; p.A845V; 16:29847841-29847841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.358G>A; p.A120T; 16:29833769-29833769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1588G>A; p.E530K; 16:29842066-29842066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1588G>A; p.E530K; 16:29842066-29842066	skin	malignant_melanoma	Substitution - Missense
c.1049C>G; p.S350*; 16:29840317-29840317	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2367G>T; p.E789D; 16:29847298-29847298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1294G>T; p.D432Y; 16:29841698-29841698	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.150G>A; p.M50I; 16:29830902-29830902	liver	carcinoma	Substitution - Missense
c.2015C>T; p.A672V; 16:29844873-29844873	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1351C>T; p.P451S; 16:29841755-29841755	skin	malignant_melanoma	Substitution - Missense
c.150G>A; p.M50I; 16:29830902-29830902	liver	carcinoma	Substitution - Missense
c.1400C>T; p.A467V; 16:29841804-29841804	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1506T>G; p.A502A; 16:29841984-29841984	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.537C>T; p.R179R; 16:29834026-29834026	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.597C>T; p.T199T; 16:29835723-29835723	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1443C>A; p.V481V; 16:29841921-29841921	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140C>T; p.I380I; 16:29840408-29840408	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.153G>T; p.V51V; 16:29830905-29830905	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.620C>T; p.A207V; 16:29835746-29835746	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.934C>A; p.P312T; 16:29840202-29840202	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.816C>T; p.P272P; 16:29836865-29836865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.P272P; 16:29836865-29836865	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.P272P; 16:29836865-29836865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.382G>C; p.D128H; 16:29833793-29833793	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.731G>T; p.R244L; 16:29836780-29836780	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1951C>T; p.R651W; 16:29844809-29844809	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1078C>T; p.R360C; 16:29840346-29840346	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1438G>A; p.V480M; 16:29841916-29841916	large_intestine; colon	carcinoma	Substitution - Missense
c.1863G>C; p.R621S; 16:29844721-29844721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1438G>A; p.V480M; 16:29841916-29841916	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1191+10G>T; p.?; 16:29840469-29840469	skin	malignant_melanoma	Unknown
c.1449G>C; p.G483G; 16:29841927-29841927	soft_tissue; striated_muscle	rhabdoid_tumour	Substitution - coding silent
c.271C>T; p.R91W; 16:29831023-29831023	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.159delC; p.P55fs*69; 16:29830911-29830911	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2300A>C; p.E767A; 16:29847231-29847231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1681C>T; p.L561F; 16:29844539-29844539	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2365G>A; p.E789K; 16:29847296-29847296	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>A; p.E412K; 16:29841638-29841638	urinary_tract; bladder	carcinoma	Substitution - Missense
c.935C>T; p.P312L; 16:29840203-29840203	skin	malignant_melanoma	Substitution - Missense
c.1234G>A; p.E412K; 16:29841638-29841638	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1234G>A; p.E412K; 16:29841638-29841638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1534C>T; p.R512C; 16:29842012-29842012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2540G>A; p.G847E; 16:29847847-29847847	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.558C>T; p.D186D; 16:29834047-29834047	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.806G>C; p.G269A; 16:29836855-29836855	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.847G>A; p.V283M; 16:29836896-29836896	oesophagus	carcinoma	Substitution - Missense
c.1018C>T; p.L340L; 16:29840286-29840286	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.813G>A; p.V271V; 16:29836862-29836862	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.959T>G; p.I320S; 16:29840227-29840227	thyroid	other; neoplasm	Substitution - Missense
c.705C>T; p.F235F; 16:29836754-29836754	skin	malignant_melanoma	Substitution - coding silent
c.1795A>G; p.I599V; 16:29844653-29844653	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>A; p.W249*; 16:29836796-29836796	breast	carcinoma	Substitution - Nonsense
c.1350G>A; p.A450A; 16:29841754-29841754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1384G>A; p.V462M; 16:29841788-29841788	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1384G>A; p.V462M; 16:29841788-29841788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.245G>A; p.R82Q; 16:29830997-29830997	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2060G>A; p.R687Q; 16:29845901-29845901	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.930C>T; p.L310L; 16:29840198-29840198	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.157G>A; p.V53I; 16:29830909-29830909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>A; p.V53I; 16:29830909-29830909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1430G>A; p.R477Q; 16:29841834-29841834	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.930C>T; p.L310L; 16:29840198-29840198	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1336C>A; p.L446I; 16:29841740-29841740	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1395C>T; p.N465N; 16:29841799-29841799	breast	carcinoma	Substitution - coding silent
c.1395C>T; p.N465N; 16:29841799-29841799	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.407A>C; p.K136T; 16:29833818-29833818	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1987G>A; p.E663K; 16:29844845-29844845	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1676C>G; p.A559G; 16:29844534-29844534	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.661C>T; p.L221F; 16:29835787-29835787	skin	malignant_melanoma	Substitution - Missense
c.1799G>T; p.R600L; 16:29844657-29844657	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2038C>A; p.L680M; 16:29845879-29845879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.596C>T; p.T199I; 16:29835722-29835722	skin	malignant_melanoma	Substitution - Missense
c.785A>T; p.D262V; 16:29836834-29836834	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2514C>T; p.P838P; 16:29847821-29847821	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1790G>A; p.R597H; 16:29844648-29844648	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1799G>A; p.R600H; 16:29844657-29844657	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1428G>T; p.K476N; 16:29841832-29841832	liver	carcinoma	Substitution - Missense
c.49C>T; p.H17Y; 16:29830598-29830598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.49C>T; p.H17Y; 16:29830598-29830598	skin	malignant_melanoma	Substitution - Missense
c.1428G>T; p.K476N; 16:29841832-29841832	liver	carcinoma	Substitution - Missense
c.2032C>G; p.Q678E; 16:29845873-29845873	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.817A>G; p.I273V; 16:29836866-29836866	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1765G>A; p.D589N; 16:29844623-29844623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.109C>T; p.R37W; 16:29830658-29830658	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation