lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	994
Symbol	CDC25B
Synonymous	-
Full name	cell division cycle 25B
Gene description	M-phase inducer phosphatase 2\|dual specificity phosphatase Cdc25B
Cytoband	20p13
Gene type	protein-coding
Synonymous	MIM:116949; HGNC:HGNC:1726; Ensembl:ENSG00000101224; HPRD:00307; Vega:OTTHUMG00000031764

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.412A>G; p.M138V; 20:3800493-3800493	liver	carcinoma	Substitution - Missense
c.1206C>T; p.I402I; 20:3802325-3802325	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1673G>A; p.C558Y; 20:3804828-3804828	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1416C>A; p.I472I; 20:3803203-3803203	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1444C>T; p.R482C; 20:3803428-3803428	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.287G>A; p.G96D; 20:3798412-3798412	skin	malignant_melanoma	Substitution - Missense
c.1500G>T; p.K500N; 20:3803484-3803484	liver	carcinoma	Substitution - Missense
c.1668C>G; p.N556K; 20:3804823-3804823	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1500G>T; p.K500N; 20:3803484-3803484	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1212C>T; p.N404N; 20:3802331-3802331	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.885C>T; p.I295I; 20:3801370-3801370	breast	carcinoma	Substitution - coding silent
c.347A>G; p.Q116R; 20:3800296-3800296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1554-8C>T; p.?; 20:3804561-3804561	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1259C>G; p.A420G; 20:3802911-3802911	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1419G>T; p.K473N; 20:3803206-3803206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.810C>T; p.S270S; 20:3801295-3801295	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691G>T; p.R564L; 20:3804846-3804846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1661A>C; p.H554P; 20:3804676-3804676	thyroid	other; neoplasm	Substitution - Missense
c.1530C>A; p.F510L; 20:3803514-3803514	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.804G>T; p.E268D; 20:3801289-3801289	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.338C>T; p.T113M; 20:3798463-3798463	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1277T>C; p.V426A; 20:3802929-3802929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.210C>T; p.R70R; 20:3797673-3797673	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.883A>T; p.I295F; 20:3801368-3801368	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1645G>C; p.E549Q; 20:3804660-3804660	oesophagus	carcinoma	Substitution - Missense
c.1171G>A; p.V391I; 20:3802290-3802290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1171G>A; p.V391I; 20:3802290-3802290	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.V148M; 20:3800767-3800767	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.V148M; 20:3800767-3800767	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.V148M; 20:3800767-3800767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1091A>G; p.D364G; 20:3802030-3802030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1621T>C; p.Y541H; 20:3804636-3804636	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1095G>A; p.T365T; 20:3802034-3802034	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1697T>C; p.M566T; 20:3804852-3804852	breast	carcinoma	Substitution - Missense
c.1008C>G; p.C336W; 20:3801947-3801947	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.294C>T; p.C98C; 20:3798419-3798419	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1653C>T; p.F551F; 20:3804668-3804668	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.244G>A; p.E82K; 20:3797707-3797707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1371G>A; p.V457V; 20:3803158-3803158	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1700A>G; p.N567S; 20:3804855-3804855	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>T; p.P308S; 20:3801740-3801740	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.209G>A; p.R70H; 20:3797672-3797672	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1367T>C; p.F456S; 20:3803154-3803154	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.224C>A; p.S75Y; 20:3797687-3797687	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.871G>C; p.G291R; 20:3801356-3801356	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1554-8C>A; p.?; 20:3804561-3804561	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.170A>G; p.Q57R; 20:3796701-3796701	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1775G>A; p.R592Q; 20:3804930-3804930	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.202C>T; p.R68C; 20:3797665-3797665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.284C>T; p.A95V; 20:3797747-3797747	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1169G>A; p.R390H; 20:3802288-3802288	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>T; p.R242M; 20:3801050-3801050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.265T>C; p.S89P; 20:3797728-3797728	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1008C>A; p.C336*; 20:3801947-3801947	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.302C>T; p.S101F; 20:3798427-3798427	skin	malignant_melanoma	Substitution - Missense
c.721C>T; p.R241C; 20:3801046-3801046	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.721C>T; p.R241C; 20:3801046-3801046	pancreas	carcinoma	Substitution - Missense
c.235C>T; p.R79W; 20:3797698-3797698	bone; vertebrae	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1445G>A; p.R482H; 20:3803429-3803429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1559G>A; p.R520H; 20:3804574-3804574	pancreas	carcinoma	Substitution - Missense
c.1559G>A; p.R520H; 20:3804574-3804574	pancreas	carcinoma	Substitution - Missense
c.1559G>A; p.R520H; 20:3804574-3804574	pancreas	carcinoma	Substitution - Missense
c.1118G>A; p.R373Q; 20:3802057-3802057	breast	carcinoma	Substitution - Missense
c.352A>G; p.I118V; 20:3800301-3800301	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>C; p.S315T; 20:3801762-3801762	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1630delA; p.G545fs*22; 20:3804645-3804645	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1251C>A; p.Y417*; 20:3802370-3802370	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1635C>T; p.G545G; 20:3804650-3804650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1550G>A; p.R517H; 20:3803534-3803534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1550G>A; p.R517H; 20:3803534-3803534	skin	malignant_melanoma	Substitution - Missense
c.303C>T; p.S101S; 20:3798428-3798428	skin	malignant_melanoma	Substitution - coding silent
c.1736G>A; p.R579H; 20:3804891-3804891	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.663G>A; p.K221K; 20:3800988-3800988	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1076G>A; p.R359Q; 20:3802015-3802015	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1389C>T; p.Y463Y; 20:3803176-3803176	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.818C>T; p.A273V; 20:3801303-3801303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.773T>A; p.L258H; 20:3801258-3801258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.201-4G>T; p.?; 20:3797660-3797660	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Unknown
c.1223G>A; p.S408N; 20:3802342-3802342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1021C>G; p.R341G; 20:3801960-3801960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1356C>G; p.I452M; 20:3803143-3803143	breast	carcinoma	Substitution - Missense
c.969A>T; p.E323D; 20:3801787-3801787	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1479C>T; p.I493I; 20:3803463-3803463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1479C>T; p.I493I; 20:3803463-3803463	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1765C>T; p.R589W; 20:3804920-3804920	skin	malignant_melanoma	Substitution - Missense
c.1201G>A; p.E401K; 20:3802320-3802320	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1789C>T; p.R597W; 20:3804944-3804944	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.984+1G>C; p.?; 20:3801803-3801803	skin	malignant_melanoma	Unknown
c.991G>A; p.V331I; 20:3801930-3801930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1282G>A; p.G428R; 20:3802934-3802934	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.450G>A; p.R150R; 20:3800775-3800775	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1742A>G; p.K581R; 20:3804897-3804897	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1665+6G>A; p.?; 20:3804686-3804686	prostate	carcinoma	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation