lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9817
Symbol	KEAP1
Synonymous	INrf2\|KLHL19
Full name	kelch-like ECH-associated protein 1
Gene description	cytosolic inhibitor of Nrf2\|kelch-like family member 19\|kelch-like protein 19
Cytoband	19p13.2
Gene type	protein-coding
Synonymous	MIM:606016; HGNC:HGNC:23177; Ensembl:ENSG00000079999; HPRD:12079; Vega:OTTHUMG00000180579

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.73G>A; p.E25K; 19:10499961-10499961	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1090G>A; p.G364S; 19:10491812-10491812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.946_951delGTGATG; p.V316_M317delVM; 19:10491951-10491956	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.803T>C; p.L268P; 19:10492099-10492099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1249G>A; p.G417R; 19:10491653-10491653	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>A; p.R272H; 19:10492087-10492087	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.932A>C; p.H311P; 19:10491970-10491970	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1423G>C; p.V475L; 19:10489756-10489756	skin	malignant_melanoma	Substitution - Missense
c.997G>A; p.G333S; 19:10491905-10491905	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>A; p.S224Y; 19:10492231-10492231	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1525G>T; p.G509W; 19:10489654-10489654	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.505C>T; p.R169C; 19:10499529-10499529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1761_1762insT; p.T588fs*31; 19:10486765-10486766	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.779G>T; p.R260L; 19:10492123-10492123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.93G>A; p.V31V; 19:10499941-10499941	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1532-2A>G; p.?; 19:10489370-10489370	lung	carcinoma; adenocarcinoma	Unknown
c.457C>T; p.L153F; 19:10499577-10499577	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1611C>T; p.Y537Y; 19:10489289-10489289	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1760A>G; p.D587G; 19:10486767-10486767	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.466A>T; p.M156L; 19:10499568-10499568	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977G>A; p.R326H; 19:10491925-10491925	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1330G>T; p.E444*; 19:10489849-10489849	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1508T>A; p.M503K; 19:10489671-10489671	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1264G>A; p.D422N; 19:10491638-10491638	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.285C>A; p.A95A; 19:10499749-10499749	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1264G>A; p.D422N; 19:10491638-10491638	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1264G>A; p.D422N; 19:10491638-10491638	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.706G>A; p.D236N; 19:10492196-10492196	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>A; p.D236N; 19:10492196-10492196	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.474T>C; p.G158G; 19:10499560-10499560	thyroid	other; neoplasm	Substitution - coding silent
c.1000T>C; p.Y334H; 19:10491902-10491902	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense
c.1165G>T; p.D389Y; 19:10491737-10491737	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.161A>G; p.Y54C; 19:10499873-10499873	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1708+2T>A; p.?; 19:10489190-10489190	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.652G>C; p.E218Q; 19:10492250-10492250	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.133T>C; p.S45P; 19:10499901-10499901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.A95T; 19:10499751-10499751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.652G>C; p.E218Q; 19:10492250-10492250	urinary_tract; bladder	carcinoma	Substitution - Missense
c.652G>C; p.E218Q; 19:10492250-10492250	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1103G>A; p.C368Y; 19:10491799-10491799	liver	carcinoma	Substitution - Missense
c.1164C>G; p.T388T; 19:10491738-10491738	ovary	other; neoplasm	Substitution - coding silent
c.1447C>A; p.R483S; 19:10489732-10489732	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	skin	malignant_melanoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.567C>G; p.N189K; 19:10499467-10499467	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1408C>T; p.R470C; 19:10489771-10489771	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.330G>A; p.M110I; 19:10499704-10499704	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1479G>C; p.E493D; 19:10489700-10489700	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.523delC; p.L175fs*55; 19:10499511-10499511	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.532C>T; p.Q178*; 19:10499502-10499502	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.399G>A; p.M133I; 19:10499635-10499635	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.132C>T; p.P44P; 19:10499902-10499902	skin	malignant_melanoma	Substitution - coding silent
c.1554_1555insT; p.I519fs*8; 19:10489345-10489346	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.444C>T; p.G148G; 19:10499590-10499590	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.554T>A; p.I185N; 19:10499480-10499480	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.44G>T; p.R15L; 19:10499990-10499990	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1650G>A; p.M550I; 19:10489250-10489250	pancreas	carcinoma	Substitution - Missense
c.1048G>A; p.G350S; 19:10491854-10491854	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1268G>T; p.G423V; 19:10491634-10491634	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.932A>G; p.H311R; 19:10491970-10491970	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.N157N; 19:10499563-10499563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.738C>G; p.F246L; 19:10492164-10492164	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.958C>T; p.R320W; 19:10491944-10491944	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.305C>T; p.S102L; 19:10499729-10499729	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.859A>T; p.K287*; 19:10492043-10492043	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.958C>T; p.R320W; 19:10491944-10491944	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409G>A; p.R470H; 19:10489770-10489770	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409G>A; p.R470H; 19:10489770-10489770	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.134C>A; p.S45Y; 19:10499900-10499900	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1413C>G; p.L471L; 19:10489766-10489766	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413C>G; p.L471L; 19:10489766-10489766	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1413C>G; p.L471L; 19:10489766-10489766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1632G>T; p.W544C; 19:10489268-10489268	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.499G>T; p.V167F; 19:10499535-10499535	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.212G>T; p.R71L; 19:10499822-10499822	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.140A>G; p.H47R; 19:10499894-10499894	liver	carcinoma	Substitution - Missense
c.140A>G; p.H47R; 19:10499894-10499894	liver	carcinoma	Substitution - Missense
c.691C>G; p.L231V; 19:10492211-10492211	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1751A>G; p.Y584C; 19:10486776-10486776	liver	carcinoma	Substitution - Missense
c.1751A>G; p.Y584C; 19:10486776-10486776	liver	carcinoma	Substitution - Missense
c.25G>A; p.G9R; 19:10500009-10500009	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1226T>C; p.M409T; 19:10491676-10491676	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.340G>T; p.G114W; 19:10499694-10499694	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.425C>T; p.T142M; 19:10499609-10499609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.425C>T; p.T142M; 19:10499609-10499609	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1189_1191delAAC; p.N397delN; 19:10491711-10491713	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.730G>A; p.E244K; 19:10492172-10492172	urinary_tract; bladder	carcinoma	Substitution - Missense
c.271G>T; p.A91S; 19:10499763-10499763	pancreas	carcinoma	Substitution - Missense
c.862T>C; p.C288R; 19:10492040-10492040	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1085G>A; p.R362Q; 19:10491817-10491817	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.271G>T; p.A91S; 19:10499763-10499763	pancreas	carcinoma	Substitution - Missense
c.1807G>T; p.G603W; 19:10486720-10486720	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1807G>T; p.G603W; 19:10486720-10486720	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.328A>G; p.M110V; 19:10499706-10499706	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.554T>C; p.I185T; 19:10499480-10499480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.793C>T; p.Q265*; 19:10492109-10492109	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.722G>A; p.C241Y; 19:10492180-10492180	liver	carcinoma	Substitution - Missense
c.793C>T; p.Q265*; 19:10492109-10492109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.722G>A; p.C241Y; 19:10492180-10492180	liver	carcinoma	Substitution - Missense
c.10G>C; p.D4H; 19:10500024-10500024	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.389C>T; p.P130L; 19:10499645-10499645	skin	malignant_melanoma	Substitution - Missense
c.246G>A; p.Q82Q; 19:10499788-10499788	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.1801C>T; p.R601W; 19:10486726-10486726	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1436A>G; p.D479G; 19:10489743-10489743	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1220C>T; p.A407V; 19:10491682-10491682	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>C; p.D236H; 19:10492196-10492196	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.706G>C; p.D236H; 19:10492196-10492196	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.187G>A; p.A63T; 19:10499847-10499847	liver	carcinoma	Substitution - Missense
c.187G>A; p.A63T; 19:10499847-10499847	liver	carcinoma	Substitution - Missense
c.1356_1357insA; p.V453fs*27; 19:10489822-10489823	breast	carcinoma	Insertion - Frameshift
c.144C>A; p.G48G; 19:10499890-10499890	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1833G>C; p.E611D; 19:10486694-10486694	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.557G>T; p.G186V; 19:10499477-10499477	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.850C>T; p.Q284*; 19:10492052-10492052	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.747delC; p.C249fs*1; 19:10492155-10492155	liver	carcinoma	Deletion - Frameshift
c.846G>A; p.Q282Q; 19:10492056-10492056	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.160T>G; p.Y54D; 19:10499874-10499874	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1628C>T; p.T543M; 19:10489272-10489272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.839T>A; p.F280Y; 19:10492063-10492063	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.929T>C; p.L310P; 19:10491973-10491973	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.958_959CG>TA; p.R320>?; 19:10491943-10491944	lung	carcinoma; adenocarcinoma	Complex
c.1609T>C; p.Y537H; 19:10489291-10489291	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>T; p.V123L; 19:10499667-10499667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1006C>T; p.R336*; 19:10491896-10491896	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.761A>C; p.K254T; 19:10492141-10492141	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.464T>C; p.V155A; 19:10499570-10499570	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.851A>T; p.Q284L; 19:10492051-10492051	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.129G>A; p.T43T; 19:10499905-10499905	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.223C>T; p.Q75*; 19:10499811-10499811	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.571G>A; p.A191T; 19:10499463-10499463	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.413A>C; p.E138A; 19:10499621-10499621	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.618C>T; p.Y206Y; 19:10499416-10499416	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1353delC; p.L452fs*6; 19:10489826-10489826	breast	carcinoma	Deletion - Frameshift
c.742G>A; p.A248T; 19:10492160-10492160	liver	carcinoma	Substitution - Missense
c.742G>A; p.A248T; 19:10492160-10492160	liver	carcinoma	Substitution - Missense
c.1252G>T; p.V418L; 19:10491650-10491650	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1519C>T; p.R507*; 19:10489660-10489660	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.403C>T; p.R135C; 19:10499631-10499631	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.492C>T; p.I164I; 19:10499542-10499542	soft_tissue; blood_vessel	angiosarcoma	Substitution - coding silent
c.492C>T; p.I164I; 19:10499542-10499542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1376G>A; p.R459Q; 19:10489803-10489803	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.58C>T; p.Q20*; 19:10499976-10499976	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1250G>A; p.G417E; 19:10491652-10491652	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1252G>A; p.V418M; 19:10491650-10491650	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.746G>A; p.C249Y; 19:10492156-10492156	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>A; p.L237M; 19:10492193-10492193	oesophagus	carcinoma	Substitution - Missense
c.1379G>T; p.R460M; 19:10489800-10489800	liver	carcinoma	Substitution - Missense
c.475G>C; p.A159P; 19:10499559-10499559	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1090G>T; p.G364C; 19:10491812-10491812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.24C>T; p.S8S; 19:10500010-10500010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.805C>T; p.R269W; 19:10492097-10492097	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.24C>T; p.S8S; 19:10500010-10500010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.912C>G; p.I304M; 19:10491990-10491990	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1516A>G; p.I506V; 19:10489663-10489663	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.373A>G; p.I125V; 19:10499661-10499661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.68G>A; p.C23Y; 19:10499966-10499966	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.811G>A; p.V271M; 19:10492091-10492091	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1509G>T; p.M503I; 19:10489670-10489670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.347G>C; p.R116P; 19:10499687-10499687	urinary_tract; bladder	carcinoma	Substitution - Missense
c.120G>A; p.A40A; 19:10499914-10499914	pancreas	carcinoma	Substitution - coding silent
c.953C>T; p.P318L; 19:10491949-10491949	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.120G>A; p.A40A; 19:10499914-10499914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1752delC; p.Y584fs*1; 19:10486775-10486775	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.498C>T; p.S166S; 19:10499536-10499536	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.959G>A; p.R320Q; 19:10491943-10491943	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1579_1580GG>TT; p.G527F; 19:10489320-10489321	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.136C>T; p.Q46*; 19:10499898-10499898	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1345G>T; p.E449*; 19:10489834-10489834	breast	carcinoma	Substitution - Nonsense
c.1345G>T; p.E449*; 19:10489834-10489834	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1083G>A; p.P361P; 19:10491819-10491819	pancreas	carcinoma	Substitution - coding silent
c.1380G>T; p.R460S; 19:10489799-10489799	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>T; p.R460S; 19:10489799-10489799	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.463G>T; p.V155F; 19:10499571-10499571	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.454_455GT>AA; p.V152N; 19:10499579-10499580	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.463G>T; p.V155F; 19:10499571-10499571	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.315T>C; p.P105P; 19:10499719-10499719	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.611G>C; p.R204P; 19:10499423-10499423	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.417C>A; p.F139L; 19:10499617-10499617	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1565C>T; p.A522V; 19:10489335-10489335	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.291G>T; p.K97N; 19:10499743-10499743	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.103_104TC>AT; p.S35I; 19:10499930-10499931	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1570G>T; p.G524C; 19:10489330-10489330	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>A; p.R260Q; 19:10492123-10492123	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.779G>A; p.R260Q; 19:10492123-10492123	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1570G>T; p.G524C; 19:10489330-10489330	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.493G>A; p.D165N; 19:10499541-10499541	breast	carcinoma	Substitution - Missense
c.493G>A; p.D165N; 19:10499541-10499541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.640G>A; p.V214M; 19:10492262-10492262	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>T; p.A556S; 19:10489234-10489234	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.939delC; p.T314fs*3; 19:10491963-10491963	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.100G>A; p.A34T; 19:10499934-10499934	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.349G>A; p.E117K; 19:10499685-10499685	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1105G>C; p.V369L; 19:10491797-10491797	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1661G>A; p.R554Q; 19:10489239-10489239	liver	carcinoma	Substitution - Missense
c.778C>T; p.R260*; 19:10492124-10492124	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1661G>A; p.R554Q; 19:10489239-10489239	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1622C>T; p.T541I; 19:10489278-10489278	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.135C>A; p.S45S; 19:10499899-10499899	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.314delC; p.P105fs*52; 19:10499720-10499720	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1447C>T; p.R483C; 19:10489732-10489732	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.431C>T; p.S144F; 19:10499603-10499603	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1429G>A; p.G477S; 19:10489750-10489750	thyroid	carcinoma	Substitution - Missense
c.1777G>T; p.E593*; 19:10486750-10486750	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1490G>T; p.W497L; 19:10489689-10489689	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1735G>T; p.D579Y; 19:10486792-10486792	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.756G>T; p.W252C; 19:10492146-10492146	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1479G>A; p.E493E; 19:10489700-10489700	skin	malignant_melanoma	Substitution - coding silent
c.1255G>T; p.G419W; 19:10491647-10491647	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1777G>A; p.E593K; 19:10486750-10486750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.287A>T; p.H96L; 19:10499747-10499747	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1677C>T; p.I559I; 19:10489223-10489223	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.997G>T; p.G333C; 19:10491905-10491905	lung	carcinoma	Substitution - Missense
c.1378A>G; p.R460G; 19:10489801-10489801	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.997G>T; p.G333C; 19:10491905-10491905	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.832C>T; p.P278S; 19:10492070-10492070	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.997G>T; p.G333C; 19:10491905-10491905	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.904_905insG; p.V302fs*48; 19:10491997-10491998	skin; upper_leg	malignant_melanoma	Insertion - Frameshift
c.149G>A; p.R50H; 19:10499885-10499885	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.483G>A; p.M161I; 19:10499551-10499551	liver	carcinoma	Substitution - Missense
c.1438G>T; p.G480W; 19:10489741-10489741	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1438G>T; p.G480W; 19:10489741-10489741	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.653A>T; p.E218V; 19:10492249-10492249	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.653A>T; p.E218V; 19:10492249-10492249	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.149G>A; p.R50H; 19:10499885-10499885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1438G>T; p.G480W; 19:10489741-10489741	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.556G>A; p.G186S; 19:10499478-10499478	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.728C>G; p.S243C; 19:10492174-10492174	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1284C>T; p.V428V; 19:10491618-10491618	pancreas	NS	Substitution - coding silent
c.134C>T; p.S45F; 19:10499900-10499900	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1243C>T; p.R415C; 19:10491659-10491659	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1715A>G; p.Y572C; 19:10486812-10486812	oesophagus	carcinoma	Substitution - Missense
c.1381A>G; p.I461V; 19:10489798-10489798	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1715A>G; p.Y572C; 19:10486812-10486812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.234C>T; p.D78D; 19:10499800-10499800	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.948G>A; p.V316V; 19:10491954-10491954	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.948G>A; p.V316V; 19:10491954-10491954	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1674G>A; p.G558G; 19:10489226-10489226	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.782G>C; p.R261P; 19:10492120-10492120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1250G>T; p.G417V; 19:10491652-10491652	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.805delC; p.R269fs*8; 19:10492097-10492097	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.970G>A; p.V324M; 19:10491932-10491932	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.572C>A; p.A191D; 19:10499462-10499462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1537T>A; p.C513S; 19:10489363-10489363	ovary	other; neoplasm	Substitution - Missense
c.847A>C; p.M283L; 19:10492055-10492055	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1607G>A; p.R536H; 19:10489293-10489293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1113C>T; p.G371G; 19:10491789-10491789	liver	carcinoma	Substitution - coding silent
c.1607G>A; p.R536H; 19:10489293-10489293	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1113C>T; p.G371G; 19:10491789-10491789	liver	carcinoma	Substitution - coding silent
c.1464G>T; p.E488D; 19:10489715-10489715	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1663A>T; p.S555C; 19:10489237-10489237	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.959G>C; p.R320P; 19:10491943-10491943	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.422A>T; p.Y141F; 19:10499612-10499612	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1630T>C; p.W544R; 19:10489270-10489270	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.299T>C; p.L100P; 19:10499735-10499735	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>A; p.P278Q; 19:10492069-10492069	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.584G>T; p.G195V; 19:10499450-10499450	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>G; p.Q563E; 19:10489213-10489213	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.346C>T; p.R116W; 19:10499688-10499688	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>A; p.A30T; 19:10499946-10499946	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>C; p.Q193H; 19:10499455-10499455	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1454A>G; p.N485S; 19:10489725-10489725	oesophagus	carcinoma	Substitution - Missense
c.295G>T; p.V99L; 19:10499739-10499739	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>C; p.Q193H; 19:10499455-10499455	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>C; p.R272P; 19:10492087-10492087	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1061G>T; p.R354L; 19:10491841-10491841	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>G; p.P278R; 19:10492069-10492069	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1392C>T; p.G464G; 19:10489787-10489787	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.218G>T; p.S73I; 19:10499816-10499816	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408C>A; p.R470S; 19:10489771-10489771	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1408C>A; p.R470S; 19:10489771-10489771	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.422A>G; p.Y141C; 19:10499612-10499612	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation